Acquired hemophilia A (AHA) also known as acquired factor VIII (FVIII) deficiency is an acquired inhibition of coagulation by antibodies that either inhibit the activity or increase the clearance of a clotting factor (FVIII). Mortality in patients presenting with AHA is related to bleeding and ...
Acquired hemophilia A, also known as acquired factor VIII deficiency, is an exceedingly rare bleeding diathesis that does not require any personal or family history of bleeding or clotting disorder. Because treatment is available, misdiagnosing or completely missing this diagnosis can be life threatenin...
Factor XIII (FXIII) is a transglutaminase consisting of 2 catalytic A subunits and 2 noncatalytic B subunits in plasma. The noncatalytic B subunits protect the catalytic A subunits from clearance. Congenital FXIII deficiency may manifest as a lifelong bleeding tendency, abnormal wound healing, and ...
Autoantibodies can develop against any coagulation cascade factor, but most commonly to VIII, IX, and XI. While con- genital forms of hemophilia are characterized by an early age of onset, the median age of presentation for the acquired deficiency is between 60 and 67 years. Clinical ...
获得性凝血因子缺乏症 Acquiredcoagulationfactordeficiency 定义 •非血友病患者产生对凝血因子Ⅷ、Ⅸ、Ⅺ、Ⅻ的抑制物，使得该凝血因子活性减低，病人出现深部软组织血肿或外伤后出血不止等类似血友病临床表现的凝血障碍性疾病 流行病学 •发病率为(0.2～1.9)/100万 •平均年龄在60岁以上,•男女分布比例大致...
Acquired esophagocele acquired essence Acquired factor IX deficiency disease Acquired factor V deficiency disease Acquired factor VII deficiency disease Acquired factor VIII deficiency disease Acquired factor X deficiency disease Acquired factor XI deficiency disease Acquired factor XII deficiency disease ...
Vaziri ND, Branson HE, Ness R: Changes of coagulation factors IX, VIII, VII, X, and V in nephrotic syndrome None of our patients exhibited acquired factor IX deficiency, a publicized complication of nephrotic syndrome. Instead, the prevalent abnormality was increased plasma factor IX activity in...
Acquired factor VIII deficiency due to antibody inhibition can result in life-threatening hemorrhage. Rarely such antibody inhibition of factor VIII can be associated with other autoimmune disorders including rheumatoid arthritis. We present the first case of a patient with active rheumatoid arthritis and...
factor VIII deficiencypediatric populationrecombinant factor VII activatedAcquired hemophilia should be evaluated in pediatric patients with bleeding and isolated prolonged aPTT. Immunosuppressive treatment should be initiated even in minor bleedings. Bypassing agents like rFVIIa can be used in children with ...
Factor VIII-related antigenhomosexualKaposi's sarcomaPalpebral conjunctivaWeibel-Palade bodiesA 38-year-old male homosexual with the new Acquired Immunodeficiency Syndrome (AIDS) had biopsy proven Kaposi's sarcoma of the right palpebral conjunctiva, extraocular mucocutaneous areas, and lymph nodes. ...