Enhancing effector function, antibody drug conjugates (ADC) or targeting multiple disease pathways via multi-specific antibodies are being explored. The manufacturing process of antibodies is also moving forward with advancements relating to host cell production and purification processes. Studies into the ...
Cassone A, Torosantucci A, Boccanera M, Pellengrini G, Palma C, Malavasi G (1988) Production and characterization of a monoclonal antibody to a cell surface, glucomannoprotein constituent of Candida albicans and other pathogenic Candida species. J Med Microbiol 27:233–238 Article CAS PubMed ...
The tool was applied to industrial case studies based on a platform monoclonal antibody purification process in a multisuite clinical scale manufacturing facility. The case studies assessed the robustness of optimal strategies to batch-to-batch titer variability and extended this to assess the long-...
High efficacy, selectivity and cellular targeting of therapeutic agents has been an active area of investigation for decades. Currently, most clinically approved therapeutics are small molecules or protein/antibody biologics. Targeted action of small molecule drugs remains a challenge in medicine. In addi...
Autoantibodies are a form of antibody which react with substances formed by a person’s own body (i.e., self-antigens) [96]. These self-antigens can be exclusive for a specific-cell type within one organ of the body or can be found in all cell-types, such as chromatin or centromere...
to melanoma cells, resulting in the relocation of aPDL1 to their surface. Hu et al. [188] combined a platelet-modified anti-PD-1 antibody with hematopoietic stem cells (HSCs) and injected them intravenously into mice with leukaemia. The HSC-platelet-aPD-1 conjugate migrated to the bone ...
High efficacy, selectivity and cellular targeting of therapeutic agents has been an active area of investigation for decades. Currently, most clinically approved therapeutics are small molecules or protein/antibody biologics. Targeted action of small molecule drugs remains a challenge in medicine. In addi...
Plant-made immunotoxin building blocks: a roadmap for producing therapeutic antibody-toxin fusions Biotechnol. Adv., 47 (2021), Article 107683 View PDFView articleView in ScopusGoogle Scholar [129] W.H. Organization WHO Guidelines on Good Manufacturing Practices (GMP) for Herbal Medicines World Hea...
to melanoma cells, resulting in the relocation of aPDL1 to their surface. Hu et al. [188] combined a platelet-modified anti-PD-1 antibody with hematopoietic stem cells (HSCs) and injected them intravenously into mice with leukaemia. The HSC-platelet-aPD-1 conjugate migrated to the bone ...
In addition, MALDI-TOF MS is not ideal for the characterization of mixed materials due to the necessity of purification, culture, and sample preparation. In addition, other chemicals, such as the matrix, are needed to conduct the tests [154]. Available databases should provide spectra that can...