TFCP2在肝细胞癌、口腔鳞状细胞癌、大肠癌、胰腺癌、宫颈癌中表达上调,而在黑色素瘤中表达下调。TFCP2在与EWSR1/FUS-TFCP2融合相关的ESRMS中过表达,但其在肿瘤发生中的作用的分子机制仍有待阐明。此外,虽然EWSR1/FUS-TFCP2融...
Here, we present a case of cutaneous rhabdomyosarcoma with FUS::TFCP2 fusion in a 35-year-old female. Notably, the tumor exhibited a pathologic spectrum, initially resembling sclerosing dermatitis at presentation but progressing into a high-grade malignant tumor within 8 months. The distinctive ...
FUS-TFCP2 and EWSR1-TFCP2 consisted of the first 254 and 138 N-terminal amino acids (aa) of FUS and EWSR1, respectively, and 460 aa of the TFCP2 protein. This corresponded to the fusion of the transcriptional activation domain and part of the first RGG1 domain of FUS or part of ...
EWSR1-TFCP2FUS-TFCP2BoneThe WHO Classification of Tumors of Soft Tissue and Bone divides rhabdomyosarcoma (RMS) into alveolar, embryonal, pleomorphic, and spindle cell/sclerosing types. Advances in molecular diagnostics have allowed for further refinement of RMS classification including the ...
Diagnostic and Therapeutic Implications of a FUS::TFCP2 Fusion and ALK Activation in a Metastatic Rhabdomyosarcomadoi:10.1002/gcc.23259Csizmok, VeronikaGrisdale, CameronJ.Williamson, LauraM.Lim, HowardJ.Lee, LawrenceRenouf, DanielJ.Jones, StevenJ.M....