We further examined theanti-SARS-CoV-2 activity of honokiol using VeroE6 cell line, which is stably expressing a transmembrane protease serine 2 (TMPRSS2). It was shown that honokiol exhibited remarkable inhibition of SARS-CoV-2 infection. Therefore, honokiol and crude drugs which contain ...
In the conserved replicase domains, Bat CoV CD35 shared 68.3%–91.5% aa identity in the 3C-like protease (3CLpro) region, 77.0%–93.1% in the RdRp region, and 81.0%–89.2% in the helicase (Hel) region with the corresponding sequences of Bat Hp-betaCoV Zhejiang2013, SARS-CoV-2, ...
proteinasecleavagesites.CellsexpressingCFRweretreatedwiththefurinproteaseinhibitordecanoyl- Arg-Val-Lys-Arg-chloromethylketone(decCMK)ortheMMP-inhibitorGM6001.Inthepresenceof furin-likePCinhibitor,secretionofCFRwasalmostcompletelyinhibited.Secretionwasnotaffectedby ...
in the polar PVS7,8,9,10,11,12. However, Tsl does not resemble any known protease, and rather belongs to the perforin-like superfamily of pore-forming proteins13. Tsl has therefore been proposed to control Trk cleavage indirectly, through controlling the activity of an unidentified protease2,...
Comparison of the molecular forms of the Kex2/Subtilisin-like serine protease SPC2, SPC3, and furin in neuroendocrine secretory vesi- cles reveals differences in carboxyl-terminus truncation and membrane association. J Neurochem 65: 2318 -2326, 1995....
It was also demonstrated that HIV infection induces the expression of either the protease activated receptor 1 (PAR1) (Kim et al., 2015) or guanylate binding proteins 2 and 5 (GBP2,5) (Braun and Sauter, 2019) that restrict the trafficking of furin to the trans Golgi network (PAR1) ...
Phospholipase Protease Angiopoietin-like 3 Endothelial Lipase Furin Knockout Mice Proprotein Convertases Introduction A large number of secretory proteins are produced as precursors that are cleaved at specific sites to generate mature bioactive products. Most of these specific cleavages occur after basic...