Furin-like Proteasedoi:10.1007/3-540-29832-0_639Furin-like protease is a prohormone convertase, a pro-protein-processing enzyme with cleavage selectivity for paired basic amino acid residues. EndothelinsSpringer Berlin HeidelbergEncyclopedic Reference of Molecular Pharmacology...
Furin is a type 1 membrane-bound protease that facilitates the entrance of the SARS-CoV-2 within the endothelial cells [22]. So far, 13 missense variants have been identified for the FURIN gene that could be associated with the susceptibility to the virus, and among them, 7 were reported ...
Furin is a membrane-associated, calcium-dependent, serine protease that belongs to the subtilisin-like prohormone convertase (PC) family. Members of this family of cellular enzymes cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial ...
In the conserved replicase domains, Bat CoV CD35 shared 68.3%–91.5% aa identity in the 3C-like protease (3CLpro) region, 77.0%–93.1% in the RdRp region, and 81.0%–89.2% in the helicase (Hel) region with the corresponding sequences of Bat Hp-betaCoV Zhejiang2013, SARS-CoV-2, ...
FURIN Also found in:Dictionary,Thesaurus,Legal,Encyclopedia,Wikipedia. A gene on chromosome 15q26.1 that encodes a ubiquitous endoprotease, located in the trans-Golgi network membrane of the Golgi apparatus, which is involved in constitutive secretory pathways, cleaving proproteins at the RX(K/R)R...
FURIN, also named FUR, PACE, PCSK3, SPC1, and Kex2p, is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and is capable of cleavage at the RX(K/R)R consensus motif. Furin is synthesized as an inactive zymogen that may minimize the occurrence of...
Background:Furin is a calcium-dependent serine endoprotease that belongs to the subtilisin-like proprotein convertase family. The members of this family process latent precursor proteins into their biologically active products. Furin cleaves at paired basic amino acid processing sites within proparathyroid...
Furin (also known as FUR, PACE, PCSK3, and SCP1) is a ubiquity expressed, calcium-dependent serine protease that belongs to the subtilisin-like proprotein convertase (PC) family (1). Furin is synthesized as a 794-amino acid type-I transmembrane protein (1). Like other PC family members,...
proteinasecleavagesites.CellsexpressingCFRweretreatedwiththefurinproteaseinhibitordecanoyl- Arg-Val-Lys-Arg-chloromethylketone(decCMK)ortheMMP-inhibitorGM6001.Inthepresenceof furin-likePCinhibitor,secretionofCFRwasalmostcompletelyinhibited.Secretionwasnotaffectedby ...
背景资料 Furin also known as paired basic Amino acid Cleaving Enzyme (PACE), is an enzyme which belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. Furin is ...