Demethylation of DNA is now accepted as being essential for embryonic development and seems to occur mainly in regions of DNA that are not CpG islands; thus, methylation patterns are increasingly being realized as being far more dynamic than previously recognized. ...
The evolving functions of DNA methylation. Curr Opin Plant Biol, 2008, 11: 554–559Zilberman D (2008) The evolving functions of DNA methylation. Curr Opin Plant Biol 11:554–559 View ArticleZilberman D.The evolving functions of DNA methylation. Current Opinion in Organ Transplantation . 2008...
DNA methylation is frequently described as a 'silencing' epigenetic mark, and indeed this function of 5-methylcytosine was originally proposed in the 1970s. Now, thanks to improved genome-scale mapping of methylation, we can evaluate DNA methylation in different genomic contexts: transcriptional start...
Thus, the occupation of a CpG island in a promoter by a transcription initiation complex may make the promoter more resistant to de novo methylation than a nonprotected transcribed region (25). Our ...Razin A: DNA methylation patterns: formation and biological functions. In: Razin A, Cedar ...
Loss of TIP60 (KAT5) abolishes H2AZ lysine 7 acetylation and causes p53, INK4A, and ARF-independent cell cycle arrest ArticleOpen access20 July 2022 The scaffolding function of LSD1 controls DNA methylation in mouse ESCs ArticleOpen access05 September 2024 ...
DNA methylation controls all genetic processes in the cell (replication, transcription, DNA repair, recombination, gene transposition) and it is a mechanism of cell differentiation, gene discrimination, and silencing. Prohibition of DNA methylation stops development (embryogenesis), switches on apoptosis,...
Hence, we hypothesized that DNMT3A may have novel functions outside of DNA methylation that regulate HSC fate decisions. To answer this question, we first ectopically expressed GFP-labeled Dnmt3a constructs (wild-type Dnmt3a, Dnmt3aE752A; complete DNA methylation dead, and Dnmt3aR832A; reduced ...
methylation,itsmultiplefunctionsandpotentialsignificanceincancer.Keywords:m6A,RNAmethylation,Cancer,MechanismBackgroundTermedas“epitranscriptome,”RNAharborsthepoten-tialofbeingdynamicallyandreversiblyregulatedbytheadditionandremovalofdistinctchemicalmoieties,whichextendstheRNArepertoireandaltersitschemis-tryinvariousways[1]...
DOT1L (DOT1-Like), possess histone methyltransferase activity toward histone H3 Lys 79, great progress has been made in characterizing their enzymatic activities and the role of Dot1/DOT1L-mediated H3K79 methylation in transcriptional regulation, cell cycle regulation, and the DNA damage response....
m5C modification of mRNA serves a DNA damage code to promote homologous recombination. Nat. Commun. 11, 2834 (2020). Article CAS PubMed PubMed Central Google Scholar Cui, X. et al. 5-Methylcytosine RNA methylation in Arabidopsis thaliana. Mol. Plant. 10, 1387–1399 (2017). Article CAS ...