DNA methylationionizing radiationcellular response to DNA damageWe studied microRNA gene expression in HeLa cells following exposure for 6 h and 8 days to Co 60 gamma rays at a dose of 4 Gy using an approach of large-scale parallel DNA sequencing. We identified 12 microRNAs with aberrant ...
What is the importance of DNA methylation? Methylation: Methylation is the process of transferring methyl groups through substitution or addition reactions to an organic compound. The transfer alters the body's chemistry. There are two basic categories of methylation: chemical and biological. ...
What is the role of RNA polymerase? Why is DNA polymerase used in PCR? What is the benefit of using TAQ polymerase in PCR? what is the difference between DNA Polymerase 1 and 3? What is the importance of DNA methylation? What is the function of polymerase 3?
Methylation of CpG dinucleotides is an epigenetic mechanism involved in the regulation of gene expression in mammals. The patterns of CpG methylation are specie and tissue specific. The biological machinery of this system comprises a variety of regulatory proteins including DNA methyltransferases, putative...
These, in turn, affect important bioprocesses such as tissue development, sex determination, and DNA damage response. Important group of proteins are responsible for adding, recognizing, and removing the methyl group to and from the RNA molecules, which are referred as writers, readers, and ...
In the offspring of the small litters POMC promoter analysis revealed hypermethylation of one CpG site (−152) within a target binding site for transcription factors Sp1 and NFκB. In addition, DNA methylation of the CpG dinucleotide within the Sp1/NFκB site was inversely correlated to the ...
DNA methylation signatures of breast cancer in peripheral T-cells Background: Immune surveillance acts as a defense mechanism in cancer, and its disruption is involved in cancer progression. DNA methylation reflects the p... S Parashar,D Cheishvili,N Mahmood,... - 《Bmc Cancer》 被引量: 0发...
Moreover, the demethylation was found to be decreased, while methylation increased from dormant bud to fruit set stage under low chill as compared to high chill conditions. In addition, RNA-Seq analysis showed high expression of DNA methyltransferases and histone methyltransferases during dormancy and...
For example, specific epigenetic modifications, including DNA methylation, H3K9 methylation and H3K79 methylation marks, and/or the related enzymes (e.g., DNMTs, HDACs, LSD1, and DOT1L) can act as barriers to the reprogramming process. Therefore, forced elimination of these epigenetic barriers ...
However, the function of HOXB13 in normal cell growth and tumorigenes... Jung,C. - 《Cancer Research》 被引量: 165发表: 2004年 Epigenetic inactivation of the candidate tumor suppressor gene HOXB13 in human renal cell carcinoma. Epigenetic alterations like DNA methylation and the resulting ...