(1) the polymerization velocity at which microtubules grow (vg), (2) the depolymerization velocity at which microtubules shrink (vs), (3) the catastrophe frequency at which microtubules switch from growth to shrinkage (Fcat), and (4) the rescue frequency at which microtubules switch from ...
Xbox One Controller Mini Wheel If racing sims are up your alley, maybe you’d prefer to alter your existing controller to fit your driving sensibilities. There are a number of ways to add some authenticity to the experience, but steering wheels can be expensive, so cheaper alternatives might ...
D Koller4, JI Nurnberger1, A Corvin5, M Geyer6, MT Tsuang6, D Salomon7, NJ Schork7, AH Fanous3, MC O'Donovan8 and AB Niculescu1,2 We have used a translational convergent functional genomics (CFG) approach to identify and prioritize genes involved in schizophrenia, by gene-level integr...
Only four of the sixA. tenebrosaSA8 genes were differentially expressed (false discovery rate (FDR) ≤ 0.05, four-fold) across the structures examined. Of these four differentially expressedA. tenebrosaSA8 genes (Fig.3A), two were upregulated in the acrorhagi (SA8_scaffold1_1 and SA8_...
Hematopoietic cells, including lymphoid and myeloid cells, can develop into phenotypically distinct 'subpopulations' with different functions. However, evidence indicates that some of these subpopulations can manifest substantial plasticity (that is, und
identified a “locked immunometabolic switch” in the same R47H homozygous iPSC line used in this manuscript, namely a defect in upregulating glycolytic energy production in response to sudden energy demands placed on the cell, for example proinflammatory stimulation [28]. Cytokine secretion, ...
up to 13 Å have been observed (Ferron et al., 2018), and crystallographic and SAXS data have shown that nsp14 undergoes important conformational changes, where the hinge might act as a molecular switch; moreover, hinge residues Y296 and P297 are essential for ExoN activity in SARS-CoV....
The role of primary cilia in mesenchymal stem cell differentiation: a pivotal switch in guiding lineage commitment. Cell Mol Bioeng. 2010;3(3):207–12. Article CAS PubMed PubMed Central Google Scholar Hoey DA, Tormey S, Ramcharan S, O'Brien FJ, Jacobs CR. Primary cilia-mediated ...
Mendes-Pereira AM, Sims D, Dexter T, Fenwick K, Assiotis I, Kozarewa I, Mitsopoulos C, Hakas J, Zvelebil M, Lord CJ, Ashworth A (2012) Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen. Proc Natl Acad Sci USA 109(8): 2730–2735. ...
In particular, changes in the expression of proteins involved in metabolism and redirection of energy flow from basic cellular function toward bone resorption appeared to play a key role in the switch from monocytic immune system function to specialized bone-turnover function. These findings provide ...