The significant results of XWAS, gene-based association analysis, eQTL analysis, and SMR analysis are included article and its additional files. The complete summary statistics generated during the current study are available from the corresponding author on reasonable request. Monocyte data were obtaine...
Summary study procedures Time interval Description of visit Measurements Hand function Questionnaires Randomization ➢ First OPD visit ➢ Hand surgeon confirms diagnosis complete UCL rupture ➢ Inclusion, signed informed consent, and randomization ➢ If logistically feasible, an ultrasound is performed...
Usage consists of several steps. We outline the general workflow here when the intention to perform imputation on chromosome 1 of our data: Munge/cleanallGWAS summary data before imputation fizi munge gwas.sumstat.gz --out cleaned.gwas
Gene-based association tests using GWAS summary statistics and incorporating eQTL Article Open access 03 March 2022 A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits Article Open access 19 December 2022 Genome-wide association testing beyond SNPs Articl...
Summary of regions with genes ranked highly by Sherlock; Genes with max-eQTL ranked as credible by PGC SCZ2 GWAS data; Isoforms with max-eQTL ranked as credible by PGC SCZ2 GWAS data (XLSX 31 kb) Supplementary Data File 3 Differentially expressed genes; Differentially expressed isoforms; Comparis...
Summary-data-based Mendelian Randomisation HEIDI: HEterogeneity In Dependent Instruments COJO: Conditional and joint association analysis TReg : Regulatory T cell References Epstein EH. Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer. 2008;8(10):743–54. Article CAS PubMed Pub...
Development of physical and mental health summary scores from the Patient-Reported Outcomes Measurement Information System (PROMIS) global items. Qual Life Res. 2009;18(7):873-880. doi:10.1007/s11136-009-9496-9PubMedGoogle ScholarCrossref 16. National Institutes of Health. HealthMeasures. http:...
HAP1 RAD51C CRISPR screen analysis reveals no interaction/epistasis with HR pathways genes and a summary of RAD51C sequencing data QC, related to Figure 1 (A) Model-based Analysis of Genome-wide CRISPR/Cas9 Knockout (MAGeCK) analysis of LIG4 KO HAP1 vs. wild-type (WT) cells. Only ...
116 metabolites from 786 individuals from a population-based twin study (TwinsUK), the fecal metabolome was found to be only modestly influenced by host genetics (heritability (H2) = 17.9%). One replicated locus at theNAT2gene was associated with fecal metabolic traits. The fecal metabolome...
The sample sizes, ancestry and phenotype summary statistics of these cohorts are given in Supplementary Table 3. The functional annotation data are publicly available and were downloaded from the following links: GRCh38 CADD v.1.4 (https://cadd.gs.washington.edu/download); ANNOVAR dbNSFP v.3.3a...