.g, Insulin secretion responses to change from G3 to G17 under the influence of 500 µmol l–1tolbutamide (Tolb) in perifusion. Normalized to secretion during the first 12 min of the test,n = 4–7; two-way ANOVA. Significance versus human islets, and when indicated, between...
(right) s-LDSC estimates from n = 1 BMI GWAS summary statistics of the heritability explained per chromosome normalized to the proportion of variants tested; data shown are percent heritability explained ± SEM (LD score regression with a block jackknife approach) (also see Supplementary...
For the HSCT cohort, gadolinium positivity is defined based on the last gadolinium scan before HSCT. ¶ Baseline was a diagnosis of CALD for the untreated cohort and a diagnosis of CALD before allogeneic HSC infusion for the HSCT cohort....
In summary, our study provides a roadmap to advance functional genomics toward the actionable disease prediction, prevention, and treatment necessary to realize personalized medicine. Limitations of the study In this study, we introduce PRIME, a high-throughput PE-mediated pooled screen platform for ...
K. et al. Partitioning heritability by functional annotation using genome-wide association summary statistics. Nat. Genet. 47, 1228–1235 (2015). CAS PubMed PubMed Central Google Scholar Watanabe, K., Taskesen, E., van Bochoven, A. & Posthuma, D. Functional mapping and annotation of ...
Transfer of convalescent plasma (CP) had been proposed early during the SARS-CoV-2 pandemic as an accessible therapy, yet trial results worldwide have been mixed, potentially due to the heterogeneous nature of CP. Here we perform deep profiling of SARS-C
sample overlap (rij) estimated from counts of cases, controls and the counts of overlaps in these groups between phenotypes70from all cohorts except FinnGen (for which we only have summary statistics). The parameter representing sample overlap between MO and MA isrij = 0.023 and MO and ...
Summary of data sets. Data were available for the stage 1 of three population-based EOC GWAS comprising a total of 4,366 cases and 9,124 controls9,18,19. An additional 11,030 cases and 21,693 controls from 41 OCAC studies were genotyped using the iCOGS array. All duplicates were ...
Genotyping, imputation and calculation of PRS, and risk gene expression were also performed. Details about how they were performed can be found in “Methods” in the Supplementary information. Ensemble clustering method based on deep learning Clustering algorithms group data points (i.e., participants...
Summary of data sets. Data were available for the stage 1 of three population-based EOC GWAS comprising a total of 4,366 cases and 9,124 controls9,18,19. An additional 11,030 cases and 21,693 controls from 41 OCAC studies were genotyped using the iCOGS array. All duplicates were remove...