Gene-expression signatures (GES), which in some ways capture biological information in a non-reductionist manner, represent powerful tools able to explore tumour heterogeneity.Twenty-five GES were used for functional annotation of breast tumours in function of age: five for molecular subtyping, seven...
Improved identification of concordant and discordant gene expression signatures using an updated rank-rank hypergeometric overlap approach. Sci Rep. 2018;8:9588. PubMed PubMed Central Google Scholar Al-Hasani R, Bruchas MR. Molecular mechanisms of opioid receptor-dependent signaling and behavior. ...
Here, the authors compare gene expression signatures in rectal tissues of African green monkeys (AGMs) and rhesus macaques (RMs) acutely infected with simian immunodeficiency virus and find that AGMs rapidly activate and maintain evolutionarily conserved regenerative wound healing mechanisms. ...
Background A recent study has shown high concordance of several breast-cancer gene signatures in predicting disease recurrence despite minimal overlap of the gene lists. It raises the question if there are common themes underlying such prediction concordance that are not apparent on the individual gene...
The evolutionary genomics of CTCF binding and functional signatures in mouse.Genetic differences within and between species predominantly lie in the noncoding sequence of the regulatory regions of the genome whose function and significance ... D Azazi 被引量: 0发表: 2020年 Mouse mutagenesis is ‘in...
The CMAP co-expression FAN is made from the Connectivity Map (CMAP) which reports drug induced gene expression signatures applied to human cancer cell lines [21]. We created a GMT file containing the top 1000 genes that either increased or decreased in expression after drug perturbation from ...
Integrative Analysis of NPM1 Mutation-Associated MicroRNA and Gene Expression Signatures Identifies Potential Leukemia-Relevant Genes in Acute Myeloid Leukemia 363 MicroRNAs (miRs) have been shown to control a wide range of biological functions such as differentiation, proliferation and apoptosis, either ...
DNA methylation is more stable than gene expression and could be used as a biomarker for early tumor diagnosis. This study is aimed to screen potential DNA methylation signatures to facilitate the diagnosis and prognosis of LUAD and integrate gene expression and DNA methylation data of LUAD to ...
Using Type Signatures (without code) to map the process “Understanding the Ontology of Measurement” Writing good clean functions that stand on their own “Working in OCaml to understand how to do QCA and how to do it well” Houston Functional Programming User Group ...
Data S1. DORC peak-gene associations for PBMC stimulation data, related to Figures 3 and 5 Data S2. Differential DORC accessibility per treatment condition per cell type, related to Figure 3 Data S3. Differential RNA expression per treatment condition per cell type, related to Figure 3 Data S4...