Functional annotation of open reading frames in microbial genomes remains substantially incomplete. Enzymes constitute the most prevalent functional gene class in microbial genomes and can be described by their specific catalytic functions using the Enzyme Commission (EC) number. Consequently, the ability ...
Functional annotation of the genes with simple sequence repeats (SSRs) into different gene ontology (GO) categories (biological process, molecular function and cellular components).Jihong, HuSongtao, GuiZhixuan, ZhuXiaolei, W...
several studies using microarrays have been initiated. These studies have used early Affymetrix technology [8–14] or filters [15], and might have missed many genes that are important to the development of a fat cell. The problem of achieving broad ...
We evaluated the extent to which molecular processes can be revealed by expression profiling and functional annotation of genes that are differentially expressed during fat cell development. Results Mouse microarrays with more than 27,000 elements were developed, and transcriptional profiles of 3T3-L1 ...
We evaluated the extent to which molecular processes can be revealed by expression profiling and functional annotation of genes that are differentially expressed during fat cell development.关键词: Animals Mice Cells, Cultured 3T3-L1 Cells Chromosomes, Mammalian Transcription Factors MicroRNAs Cluster ...
Variant Annotation is required to obtain information on biological consequences of SNPs in the risk loci. There are several tools such as ANNOVAR12and VEP28which annotate functional consequences on genes, and variant scores such as deleteriousness and phylogenetic conservations (extensive review is avai...
positive tumors (P < 0.001), the functional annotation of which revealed a preponderance of genes that play a role in cellular immune response and ... M Grade,P Hormann,S Becker,... - 《Cancer Research》 被引量: 286发表: 2007年 Gene expression signature of estrogen receptor α status in...
Annotation of genes with GO terms creates a biological knowledge profile, in three layers dependent on the top-level GO branch used (biological process, molecular function or cellular component). Several tools are suited for analysis of the GO hierarchy and for statistical evaluation of GO category...
Interpretation of ever-increasing raw sequence information generated by modern genome sequencing technologies faces multiple challenges, such as gene function analysis and genome annotation. Indeed, nearly 40% of genes in plants encode proteins of unknown function. Functional characterization of these genes...
The genomes of trypanosomatids are distantly related to other eukaryotes, with significant numbers of hypothetical or conserved hypothetical trypanosomatid-specific genes, whose functions cannot be determined using homology-dependent annotation methods. Here, we describe homology-independent methods to infer bi...