功能指向性合成 Function-Oriented Synthesis 不拘泥于一定化合物的结构,主要注重于功能的再现或者优化为目的的合成法,被称为功能指向性合成(Function-Oriented Synthesis, FOS)。斯坦福大学的Paul A. Wender (标题图引用于文献[1]) 功能指向性合成(FOS)所带来的「从重视结构到注重功能的SHIFT」,直接影响了合成策略的...
Function-oriented synthesis of a class of liponucleoside antibiotics was investigated through rational simplification guided by previous structureactivity relationship studies of caprazamycins and muraymycins to address the issue associated with their molecular complexity. A lactam-fused isoxazolidine scaffold...
aSynthesis and Characterization of Impurities of Barnidipine Barnidipine杂质的综合和描述特性[translate] aridge 土坎[translate] aport in = 3.5 口岸在= 3.5[translate] ain this series of emails, you will learn everything you need to know about alkaline water, its effects, and how to best use it...
面向功能的图标5) the Synthesis Method of Orienting Function 面向功能的复合法 1. The Synthesis Analysis and Design for the Synthesis Method of Orienting Function; “面向功能的复合法”的系统分析与设计方法6) Object-Oriented Method Function Poin(tOOMFP) 面向对象方法的功能点补充...
It is important to pursue function-oriented synthesis (FOS), a strategy for the design of less structurally complex targets with comparable or superior activity that can be made in a practical manner, because compared to synthetic drugs, many biologically relevant natural products possess large and ...
Yet, novel strategies for producing engineered molecular channels are few. Here, we report a peptide engineering strategy through sequence reversal, which we applied on the first transmembrane peptide of the mycobacteriophage membranoporin protein holin. We have successfully re-designed the membrane ...
This Account provides an overview and examples of function-oriented synthesis (FOS) and its increasingly important role in producing therapeutic leads that can be made in a step-economical fashion. Biologically active natural product leads often suffer from several deficiencies. Many are scarce or ...
Function-Oriented Synthesis: Studies Aimed at the Synthesis and Mode of Action of 1-Alkyldaphnane Analogues.An efficient synthetic route to the ABC tricyclic core of 1-alkyldaphnanes has been developed. The conformational bias imparted by the C6−C9 oxo-bridge of BC-ring system 12was ...
Translating nature’s library: the bryostatins and function-oriented synthesis - Schrier, Loy, et al.Wender PA, Loy BA, Schrier AJ. Translating Nature's Library: The Bryostatins and Function-Oriented Synthesis. Israel journal of chemistry. 2011; 51 :453–472....
Wender, P. A.; Verma, V. A.; Paxton, T. J.; Pillow, T. H. Function-oriented synthesis, step-economy, and drug design. Acc. Chem. Res. 2008, 41, 40-49.Wender P.A., Verma V.A., Paxton T.J., Pillow T.H. (2008) Function-oriented synthesis, step economy, and drug design...