功能指向性合成 Function-Oriented Synthesis 不拘泥于一定化合物的结构,主要注重于功能的再现或者优化为目的的合成法,被称为功能指向性合成(Function-Oriented Synthesis, FOS)。斯坦福大学的Paul A. Wender (标题图引用于文献[1]) 功能指向性合成(FOS)所带来的「从重视结构到注重功能的SHIFT」,直接影响了合成策略的...
Yet, novel strategies for producing engineered molecular channels are few. Here, we report a peptide engineering strategy through sequence reversal, which we applied on the first transmembrane peptide of the mycobacteriophage membranoporin protein holin. We have successfully re-designed the membrane ...
. The size and sign of the effect often depends on whether the modulating stimulus is located in the end zones versus the side zones of an oriented CRF. The effect may also depend on other properties of the modulating stimulus, such as its orientation or contrast. Scale bars in orthographic...
FIGURE 8. Synthesis functions. (Left) Nearest-neighbor. (Right) Linear. φ0(x)={0x<−121−12≤x<12012≤x. The main interest of this synthesis function is its simplicity, which results in the most efficient of all implementations. In fact, for any coordinate x where it is desired to...
One of the persistent communities identified corresponds to a family of Transducin-Like Enhancer (TLE) proteins that interact with the Nsp13 RNA synthesis protein in SARS-COV2. This interaction could potentially form the basis for a drug target since TLEs are known to inhibit the WNT pathway, ...
et al. Vasoactive intestinal polypeptide-expressing interneurons in the hippocampus support goal-oriented spatial learning. Neuron 101, 1150–1165.e8 (2019). In this synergetic study, experiments show that diverse populations of VIP + interneurons control learning-induced place cell enrichment in CA1;...
The stage of meiosis II or second mitotic division has a purpose similar to that of mitosis where the two new chromatids are oriented in two new daughter cells. Therefore, the second meiotic division is sometimes referred to as separation division of meiotic division....
Alternative 3D plenoptic functions can be obtained, for example, by placing cameras on a circle, oriented toward the outside of the circle. Finally, if we constrain camera position to a single point, we have a 2D function that is in fact a common still image.For...
HCA by AuNP38. In their work, the authors show that introducing functional groups with histidine-like imidazole rings on AuNP could support the activity of the adsorbed HCA. This result also suggests the channel of proton shuttling is oriented toward the AuNP surface, as predicted by our ...
1. The Synthesis Analysis and Design for the Synthesis Method of Orienting Function; “面向功能的复合法”的系统分析与设计方法2) Object-Oriented Method Function Poin(tOOMFP) 面向对象方法的功能点3) control-oriented function 面向控制的功能