of antiaggregation and vasodilation; (ii) the interplay of insulin with substances able to activate adenylate cyclase in both cell types; (iii) the impairment of the antiaggregating insulin effects in insulin-resistant subjects; (iv) the insulin-induced increase on endothelin in the VSMCs; (v)...
Overweight Hispanic children with a family history of type 2 diabetes may represent a unique population given that pubertal insulin resistance was not evident once analyses controlled for body composition. Longitudinal analyses are required to determine whether the slightly diminished β-cell function in ...
Our study aims to test the hypothesis that poorer function of cardiac mitochondria in males, under sex hormone-deprived and obese-insulin-resistant conditions, is responsible for a worse cardiometabolic function than females. Methods One hundred and forty-four rats were subjected to receive either 12...
In addition, CAMP has been shown to exert a selective effect on the transcription of the insulin gene (47). By using inhibitors of polyamine biosynthesis it was recently shown that increased synthesis of spermidine and sperrnine is necessary for glucose stimulated insulin gene expression (80). ...
The effects of insulin on pressor responsiveness to alpha agonist (phenylephrine) and angiotensin II, and baroreflex function were studied in fifteen diabetic patients without autonomic neuropathy. The dose of phenylephrine required to increase systolic pressure by 25 mmHg (PD25) was significantly increas...
The effects of insulin on cardiomyocytes, such as positive inotropic action and glucose uptake are well described. However, in vitro studies comparing long-acting insulin analogues with regard to cardiomyocyte signalling and function have not been systematically conducted. Insulin receptor (IR) binding ...
To determine the relationship between insulin sensitivity and beta-cell function, we quantified the insulin sensitivity index using the minimal model in 93 relatively young, apparently healthy human subjects of varying degrees of obesity... SE Kahn,RL Prigeon,DK Mcculloch,... - 《Diabetes》 被引...
1. The effects of vagal efferent fibre stimulation on the smooth muscle of the lower oesophageal sphincter have been studied on the anaesthetized animal an... J Gonella,JP Niel,C Roman - 《Journal of Physiology》 被引量: 133发表: 1979年 The Action of Insulin, Growth Hormone, and Epinephrin...
Nanoparticles and nano-delivery systems are constantly being refined and developed for biomedical applications such as imaging, gene therapy, and targeted delivery of drugs. Nanoparticles deliver beneficial effects by both release of their cargo and by l
, c-AMP response element binding protein 1 (CREB1;z-score = 2.0), and insulin growth factor receptor 1 (IGFR1;z-score = 1.9) (allP < 0.05 of the Fisher’s test), with all these genes predicted to be inhibited in female LR/Stat3Δ/Δcounterparts (Supplementary Table3)....