Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency. Female mammals are endowed with a finite number of oocytes at birth, each enclosed by a single layer of somatic (granulosa) cells in a primordial follicle... GI Perez,R Robles,CM Knudson,... - 《Nature Geneti...
The gonadotropins, follicle-stimulating hormone (FSH), and luteinizing hormone (LH), are of particular importance in ovarian physiology. However, FSH receptors and LH receptors are not expressed until the secondary follicle stage, indicating that initiation of follicular growth is independent of the ...
and multiple studies have shown that thyroid abnormalities, especially during adolescence and reproductive age, can lead to lifelong ovarian dysfunction. Autoimmune thyroid disease (AITD), one of the most common organ specific autoimmune diseases, is mainly mediated by cellular autoimmune reactions, and ...
Intragonadal factors initiate growth of the follicle and coordinate development of the oocyte, granulosa cells, and thecal cells (1) . Extragonadal factors, particularly hormones from the pituitary, synchronize granulosa cell and theca cell function later in folliculogenesis to initiate puberty and ...
During the follicular phase, primordial follicles are called upon to initiate a process of follicular development which culminates in ovulation. However, the release of an oocyte belies the fact that the postovulatory follicle has yet another role to play in the luteal phase. Therein, it adopts ...
A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause. : BACKGROUND The primary determinant of reproductive age in women is the number of ovarian non-growing (primordial, intermediate and primary) follicles (NG... KR Hansen,NS Knowlton,AC...
Global activation of primordial follicles in artificial ovaries can result in further rapid loss of germ cells. Methods for maintaining self-renewal and expansionof PGCs and controlling follicle activation will be essential for continuing maintenance of the functional reconstructed ovaries....
Deficiency of Pdk1 contributes to primordial follicle activation via the upregulation of YAP expression and the pro‑inflammatory response The molecular mechanisms underlying the activation of primordial follicles are poorly understood. The serine/threonine protein kinase phosphoinositidedepen... J Gao,T ...
(singular oogonium), which come from primordial germ cells during fetal development. The oogonia multiply by mitosis, asomatic celldivision process where daughter cells have the same amount of cellular material and chromosomes (DNA) as its parent cell, making it diploid. When the oogonia become ...
fertility, cycle irregularity, and, eventually, menopause. This is a natural process since the continuous activation of primordial follicles leads to the depletion of the follicular ovarian reserve. There are many factors that contribute to accelerate the ovarian aging. Many of them are still not ...