Where can enzymes function in the body? What are the main functions of pancreas apart from producing enzymes? Why does cell need enzymes? What is the role of enzymes as a catalyst? What enzymes are found in the stomach and what are their functions?
Muscle fructose-1,6-bisphosphate aldolase (ALDOA) is among the most abundant glycolytic enzymes in all cancer cells. Here, we show that the enzyme plays a previously unknown and critical role in a cancer cell survival. Simultaneous inhibition of ALDOA activity and interaction with F-actin cytoskel...
The nature and assembly of the chlamydial division septum is poorly defined due to the paucity of a detectable peptidoglycan (PG)-based cell wall, the inhibition of constriction by penicillin and the presence of coding sequences for cell wall precursor and remodelling enzymes in the reduced chlamyd...
The mitochondrial DNA is restricted to the matrix that also contains a host of enzymes and ribosomes needed for protein synthesis. Several of the critical metabolic steps of cellular respiration are being catalyzed by the enzymes that can diffuse through the mitochondrial matrix. The enzyme that gen...
Microbes utilize enzymes to perform a variety of functions. Enzymes are biocatalysts working as highly efficient machines at the molecular level. In the past, enzymes have been viewed as static entities and their function has been explained on the basis of direct structural interactions between the ...
Organelle, any of the specialized structures within a cell that perform a specific function (e.g., mitochondria, ribosomes, endoplasmic reticulum). Organelles in unicellular organisms are the equivalent of organs in multicellular organisms. The contracti
As recently as a decade ago, little was known about the three-dimensional structure of the enzymes involved in these highly branched biosynthetic pathways. Ten years ago, we initiated X-ray crystallographic analyses of key enzymes of this pathway, complemented by biochemical and enzyme engineering ...
(integral protein) ◼ To penetrate all the way through membrane ◼ Function: ① provide structural channels for water molecules, water-soluble substances especially ions; ② act as carrier proteins for transporting substances not penetrating the lipid bilayer; ③act as enzymes Functions of memb ...
For example, structural proteins maintain cell shape, akin to a skeleton, and they compose structural elements in connective tissues like cartilage and bone in vertebrates. Enzymes are another type of protein, and these molecules catalyze the biochemical reactions that occur in cells. Yet other ...
The specific activity of enzymes can be altered over long timescales in cells by synonymous mutations that alter a messenger RNA molecule’s sequence but not the encoded protein’s primary structure. How this happens at the molecular level is unknown. Here, we use multiscale modelling of three ...