aI'm sorry, DHL Delay for a while, You will receive the order on 15th. 我有一阵子抱歉, DHL延迟,您将接受订单在第15。[translate] aDual role of the caspase enzymes in satellite cells from aged and young subjects caspase酵素的双重角色在卫星细胞从年迈的和年轻主题[translate]...
Cellsthe Degradation of Nucleosomes of Apoptotic Role of Macrophage Lysosomal Enzymes in lysosomal enzymes of macrophages, e.g., DNase II-like acid DNase and cathepsins, are responsible for the degradation of nucleosomes of apoptotic cells. ... C Odaka,T Mizuochi 被引量: 0发表: 1999年 ...
Precursors of lysosomal enzymes are synthesized in the rough endoplasmic reticulum (rER) and then migrate to the cis-Golgi, where mannose residues on the oligosaccharide chain are phosphorylated to form mannose-6-phosphate (M-6-P), an important sorting signal for lysosomal enzymes. In the trans-...
which is linked with chromatin condensation, DNA damage response, and transcription (Table1).59,60Histone can be heavily modified on lysine residue by ubiquitin. Ubiquitination enzymes (E1 activating, E2 conjugating, and E3 ligase enzymes) and deubiquitinating...
CTLs are capable of secreting cytotoxic molecules such as granular enzymes and perforin, as well as pro-inflammatory cytokines like IFN-γ, TNF-α, and IL-9. They also promote apoptosis of TCs by expressing death ligands, such as FasL. Consequently, CTLs are considered a crucial effector ce...
Interestingly, one exception are macrophages of the intestine where embryonic precursor cells are replaced in an ongoing process by bone marrow derived Ly6Chigh monocytes that differentiate locally (Bain et al., 2014).Fig. 1 The separate development of monocytes as a distinct line of cells and ...
General roles of DUBs and DUBs specificity Ubiquitination, the process in which ubiquitin (Ub) that conjugate ubiquitin to targeted proteins through a cascade composed of E1, E2 and E3 enzymes, plays a vital role in multiple biological processes [1]. Ubiquitin contains seven lysine residues in to...
In the last few decades, the role of cancer stem cells in initiating tumors, metastasis, invasion, and resistance to therapies has been recognized as a potential target for tumor therapy. Understanding the mechanisms by which CSCs contribute to cancer progression can help to provide novel therapeuti...
Zemanová, N., Anzenbacher, P., Zapletalová, I.et al.The role of the microbiome and psychosocial stress in the expression and activity of drug metabolizing enzymes in mice.Sci Rep10, 8529 (2020). https://doi.org/10.1038/s41598-020-65595-9 ...
Metformin in AMPK-mediated mechanisms leads to reduced liver glucose production and an increase in its consumption. AMPK is, indeed, considered as the main regulator of sugar and fat metabolisms. Ampk activation results in a diminish in the production of lipogenic enzymes, the induction of fatty ...