From a conceptual standpoint, the COX-2 hypothesis of late PC expands our understanding of the function of this enzyme in the cardiovascular system and impels a critical reassessment of current thinking regarding the biologic significance of COX-2.[Copyright &y& Elsevier]Bolli...
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Cytochrome P450 3A4 (CYP3A4) is the main metabolism enzyme of fentanyl, and sin... Z Dong,H Li,Q Chen,... - 《Journal of Clinical Pharmacy & Therapeutics》 被引量: 0发表: 2012年 Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually ...
Expression and function of protein kinase C-α and β I isoenzymes in drug-resistant gastric cancer cells. Cyclo-oxygenase-2 (COX-2) is the inducible enzyme in the gastric mucosa responsible for prostaglandin production during inflammation and ulcer healing. The... Y Han,Y Shi,L Li,... 被...
The clearance rate is different for each hormone and is influenced by compounds that alter liver enzyme activity involved in hormone clearance. Many pesticides induce the liver enzymes monooxygenase and UDP-glucuronosyltransferase [44], resulting in increased clearance of the pesticide itself for ...
. Work in the last decade has begun to clarify the complex signals that lead to acquisition of this blood-forming potential. Our understanding of the events that lead to hemogenic specification of endothelial cells from vascular endothelium, as well as the events that lead to generation of HSPC...
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The biogenesis of the inner mitochondrial membrane enzyme cytochrome c oxidase (COX) is a complex process that requires the actions of ancillary proteins, collectively called assembly factors. Studies with the yeast Saccharomyces cerevis... JM Zee,Glerum, D. Moira - 《Biochemistry & Cell Biology》...
of reactive oxygen species (ROS) exposure (i.e., released from damaged mitochondria), which results in the leakage of lysosomal enzymes to the cytoplasm, inducing proinflammatory events such as inflammasome activation. Lysosomal dependent cell death is the consequence of massive lysosomal enzyme ...
Cardiovascular disease and resuscitated septic shock lead to the downregulation of the H2S-producing enzyme cystathionine-γ-lyase in the porcine coronary artery. Intensive Care Med. Exp. 5, 17 (2017). Article Google Scholar Giannakopoulou, E. et al. Association study of the ...