Conclusions: COX-1 deficiency or inhibition and short-term COX-2 inhibition are compatible with normal small intestinal integrity. Dual inhibition of the COX enzymes leads to damage similar to that seen with indomethacin. Long-term COX-2 deficiency or inhibition is associated with significant ...
吲哚美辛是一种非选择性抑制剂环氧合酶 (COX) 1 和 2,参与从花生四烯酸前列腺素合成的酶 翻译结果4复制译文编辑译文朗读译文返回顶部 nonselectiveindomethacin是一个cyclooxygenase抑制剂(cox)1、2、酶的合成,参与名arachidonic酸 翻译结果5复制译文编辑译文朗读译文返回顶部 正在翻译,请等待... 相关内容 a大家好,...
Related to Cox-1:Cox-2 COX-1 (kŏks′wŭn′) n. One of two isoenzymes that catalyze the conversion of arachidonic acid into prostaglandins. It is present in cells throughout the body and is inhibited by NSAIDs. [c(yclo)ox(ygenase).] ...
ARealTimeQuantitativePCRAnalysisandCorrelationof COX-1andCOX-2EnzymesinInflamedDentalPulps FollowingAdministrationofThreeDifferentNSAIDs ClaudiaI.Holt,DDS,MS,*MaxO.Hutchins,PhD †† ,andRobertaPileggi,DDS,MS* Abstract Dentalpainisencountereddailybyclinicians.Nonste- roidalanti-inflammatorydrugs(NSAIDs)comm...
Conclusions: COX-1 deficiency or inhibition and short-term COX-2 inhibition are compatible with normal small intestinal integrity. Dual inhibition of the COX enzymes leads to damage similar to that seen with indomethacin. Long-term COX-2 deficiency or inhibition is associated with significant ...
The enzymes that convert arachidonic acid to prostaglandin H2 are named cyclooxygenase-1 (COX-1) and COX-2. The properties of COX-1 are different from those of COX-2. It was originally thought that the function of COX-1 was involved in physiological phenomena, whereas that of COX-2 was ...
Cyclooxygenases (COXs) are the rate limiting enzymes in the process of prostaglandins (PGs) synthesis, which are critical regulators of a number of reproductive processes, including ovulation, implantation, decidualization and parturition. The aim of the present study was to investigate the expression...
Cyclooxygenases are key enzymes in the conversion of arachidonic acid to prostaglandins. The COX family consists of two isoforms, COX-1 and COX-2. In the brain, COX-2 is constitutively expressed at high levels on pyramidal neurons, while COX-1 is predominantly expressed by microglia and can ...
The recognition that there are two cyclo-oxygenase enzymes, one predominating at sites of inflammation (COX-2) and one constitutively expressed in the gastrointestinal tract (COX-1), has led to the important therapeutic development of COX-2 inhibitors. COX-2 is phylogenetically more primitive that...
Also, neuronal elements did not show COX-1 or COX-2 immunoreactivity. These results establish the presence of COX-1 and COX-2 on the RNA and protein levels in normal, unstimulated rabbit iris and ciliary body. The pattern of distribution suggests a role for both enzymes in maintaining the ...