An interesting study indicating that CAFs aquire a pro-inflammatory gene expression programme in the early stages of neoplasia. CAS PubMed Google Scholar Dolberg, D. S., Hollingsworth, R., Hertle, M. & Bissell, M. J. Wounding and its role in RSV-mediated tumor formation. Science 230, ...
N. Regulation of mitochondrial biogenesis as a way for active longevity: interaction between the Nrf2 and PGC-1alpha signaling pathways. Front. Genet. 10, 435 (2019). Article CAS PubMed PubMed Central Google Scholar Scarpulla, R. C. Nuclear control of respiratory gene expression in mammalian...
Remarkably, expression of an activated form of Braf in Shp-2-deficient mice restores ERK activation, goblet cell production, and prevents colitis. Altogether, our results indicate that chronic activation of Shp-2/ERK signaling in the colonic epithelium confers resistance to mucosal erosion and ...
“gain-of-function” mutations inoncogenes. Hence Vilaret al.243reported that PI3K-AKT is a potential therapeutic target forMMRdeficientcolorectal cancers. Other studies from Solitet al.244reported that BRAF mutation predicts sensitivity to MEK inhibition. These data highly suggested that “gain-of-...
Mutations of the BRAF gene in human cancer Nature, 417 (2002), pp. 949-954 View in ScopusGoogle Scholar [72] S.S. Sridhar, D. Hedley, L.L. Siu Raf kinase as a target for anticancer therapeutics Mol. Cancer Ther., 4 (2005), pp. 677-685 View in ScopusGoogle Scholar [73] D. ...
BRAF gene mutations have been associated with human cancers. Among the naturally occurring mutations, two that involve amino acids of the conserved DFG motif in the activation loop (D594V and G596R), appear to be inactivating. Aim of this study was to analyze the molecular mechanisms involved...
They screened this library to identify genes that confer resistance to a melanoma drug called PLX-4720. Drugs of this type work well in patients whose melanoma cells have a mutation in the BRAF gene, but cancer cells that survive the treatment can grow into new tumors, allowing the cancer to...
Joshi, R. L. et al. Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality.EMBO J.15, 1542–1547 (1996). ArticleCASPubMedPubMed CentralGoogle Scholar Bruning, J. C. et al. A muscle-specific insulin receptor knockout exhibits features of the metabolic ...
Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ. Cancer Res. 74, 3205–3217 (2014). Article CAS PubMed PubMed Central Google Scholar Perrot, I. et al. Dendritic cells infiltrating human non-small cell lung cancer are blocked at immature stage. J. ...
A method to identify cells that are expressing or have expressed a gene of interest at any point during their development, which enables the study of progenitor–progeny relationships. E protein A member of a family of transcription factors, including TCF3 (also known as E2A), TCF4 (also know...