BRAF gene mutations have been associated with human cancers. Among the naturally occurring mutations, two that involve amino acids of the conserved DFG motif in the activation loop (D594V and G596R), appear to be inactivating. Aim of this study was to analyze the molecular mechanisms involved...
Mutations of the BRAF gene in human cancer Nature, 417 (2002), pp. 949-954 Google Scholar [72] S.S. Sridhar, D. Hedley, L.L. Siu Raf kinase as a target for anticancer therapeutics Mol. Cancer Ther., 4 (2005), pp. 677-685 Google Scholar [73] D. Strumberg, S. Seeber Raf kin...
A method to identify cells that are expressing or have expressed a gene of interest at any point during their development, which enables the study of progenitor–progeny relationships. E protein A member of a family of transcription factors, including TCF3 (also known as E2A), TCF4 (also know...
MicroRNAs (miRNAs) are small non-coding RNAs that guide post-transcriptional gene regulation to shape the rate at which genetic information is converted into proteins. Due to this, miRNAs contribute to the establishment of gene expression patterns that are required for normal development and physiology...
Overview of bioinformatic steps for transcriptome reconstruction and identification of unknown gene loci, followed by categorization and functional categorization. GV: oocyte in the germinal vesicle stage; MII: oocyte in the metaphase II stage; 8c: eight cell stage embryos; BL: blastocysts Full size ...
Relevance of mutations in protein deubiquitinases genes and TP53 in corticotroph pituitary tumors They commonly cause Cushing's disease (CD), however, some remain clinically silent. Recurrent USP8, USP48, BRAF and TP53 mutations occur in corticotroph... MP Kul,M Szczepaniak,P Kober,... - 《...
International Journal of Molecular Sciences Article BRAF and MEK Inhibitors Influence the Function of Reprogrammed T Cells: Consequences for Adoptive T-Cell Therapy Jan Dörrie 1,†, ID Lek Babalija 1,2,†, Stefanie Hoyer 1, Kerstin F. Gerer 1,2, Gerold Schuler 1, Lucie Heinzerling 1...
mutations in oncogenes. Hence Vilaret al.243reported that PI3K-AKT is a potential therapeutic target for MMR deficient colorectal cancers. Other studies from Solitet al.244reported that BRAF mutation predicts sensitivity to MEK inhibition. These data highly suggested that “gain-of-function” mutatio...
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. The classical type of programmed cell death is characterized by its dependence on de novo RNA and protein synthesis and morphological features of apoptosis... Y,Ishida,Agata,... - 《...
The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-canc