SUMO modification of human XRCC4 regulates its localization and function in DNA double-strand break repair. Mol Cell Biol 2006; 26:1786. Article CAS PubMed PubMed Central Google Scholar Matunis MJ, Coutavas E, Blobel G . A novel ubiquitin-like modification modulates the partitioning of the...
single perturbations in mouse ‘knockouts’ experiments using gene targeting, which can define the function of genes and construct biological networks[52]. Nadeau et al.[54], constructed functional networks for cardiovascular traits based on experiments of multiple genetic perturbatio...
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It is also marketed to counter the effects of aging, reverse degenerative diseases, improve general health, increase vitality and stamina, and enhance sexual function. Some practitioners have proposed using cell therapy to treat AIDS patients. However, available scientific evidence does not support ...
We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
have shown that melanoma cells impair the function of NK cells through inhibiting the expression of major receptors including NKp30, NKp44 and NKG2D which are associated with cytolytic activity. Further, they have observed that this inhibitory effect was primarily mediated by indoleamine 2,3-...
Results: This article provides new insights about the pathogenesis of VuM based on single-cell resolution data. It was found that the activation of CD8 T cell contributed to induce tumor angiogenesis and immune escape, and the activation of the antigen-presenting molecular f...
Canonical regulation by the neddylation process involves the modification of cullin family proteins with NEDD8. Cullin family members, which function as scaffold proteins for the cullin-RING ubiquitin ligase (CRL), are the most extensively studied targets of neddylation10. Inactive CRLs are activated ...
of novel single-cell methodologies, such as mass cytometry or cytometry with time-of-flight (CyTOF) analysis, allows high-throughput multi-parametric analysis of cellular heterogeneity23. Mass cytometry has provided unprecedented insights into normal tissue function24,25and tumour biology, including the...