Background: The human APOE gene is encoded by three distinct alleles (APOE2, E3 and E4), each giving rise to a unique protein isoform. The APOE4 allele is a well established genetic risk factor for Alzheimer's disease (AD), and is purported to influence the risk of cognitive impairment...
Studies over the last decade have elucidated the role of protein–protein interaction domains in a variety of cellular processes[1]. A large number of intracellular protein–protein interaction domains have been identified to date because of the increase in gene cloning and the use of advanced comp...
MAIN OUTCOME MEASURES: Correlation of ApoE gene frequency and ApoE epsilon 4 allele to MMSE scores was measured. RESULTS: MMSE scores in patients from the gas anesthesia group significantly decreased 3 days after surgery, compared with the intravenous anesthesia group. The proportion of patients that...
The ε4 allele of the APOE gene encoding apolipoprotein E (apoE) is a strong genetic risk factor for aging-related cognitive decline as well as late-onset Alzheimer's disease (AD) compared to the common ε3 allele. In the central nervous system, apoE is produced primarily by astrocytes and...
Cell type-specific roles of APOE4 in Alzheimer disease Article08 January 2024 Introduction Inherited variation in the sequence of apolipoprotein E (apoE) is the greatest genetic risk factor for late-onset Alzheimer’s Disease (AD), which accounts for ~95% of all AD cases1. TheAPOEgene has th...
方法 将32只ApoE基因敲除小鼠随机分为4组,即成年中药组、老年中药组、成年模型组及老年模型组,每组8只;将16只相同遗传背景C57BL/6J小鼠随机分为2组,即成年正常组及老年正常组,每组8只。成年组小鼠至24周起、老年组小鼠至32周起,中药组以通脉益智胶囊灌胃12周,模型组与正常组以同容积0.9%氯化钠注射液灌胃12周...
although a number of pathogenic processes, including oxidative stress, excitotoxicity, inflammation, and mitochondrial and neurofilament dysfunction, are thought to play important roles. Ten percent of cases of ALS are familial, and in 20% of these, a causative mutation is found in the gene encoding...
The bridging integrator 1 (BIN1) gene, also known as amphiphysin 2, has recently been identified as the most important risk locus for late onset Alzheimer's disease (LOAD), after apolipoprotein E (APOE). Here, we summarize the known functions of BIN1 and discuss the polymorphisms associated wi...
A second class of AD risk factor is genetic variation that modulates the sporadic late onset AD; at present, the sole member of this class is the APOE gene. APOE encodes a secreted protein of 299 amino acids important for the transport of cholesterol. Single nucleotide polymorphisms (SNP) def...
Here, we explore the ASO-mediated RNase-H reduction ofAPOEandTREM2expression, two of the major risk genes for AD, in human microglia both in vitro and in vivo.We identify potent ASOs targeting humanAPOEandTREM2that reduce their target gene expression at the RNA and at the protein level in...