The strongest genetic risk factor for sporadic AD is the presence of the ε4 allele of the apolipoprotein E (ApoE) gene, the major apolipoprotein involved in brain cholesterol transport [2,3]. Indeed, changes in lipid metabolism, in particular that of choles- terol, predispose to AD playing ...
. Hif1a was shown to be present in macrophage-rich and foam cell-rich areas and its expression in macrophages was correlated with accelerated atherosclerosis development in LDLR-/-mice [12]. Moreover, it has been shown that hypoxia can influence gene expression in macrophages, leading to an ...