Scaffolding proteins encoded by the stardust gene are novel components of the Crumbs complex, which plays a critical role in ZA assembly.[1-3] The small GTPase Rap1 controls the symmetric re-assembly of the ZA after cell division.[4] Finally, the asymmetric distribution of adherens junction ...
Polyamine depletion did not alter expression of tight junction proteins such as zona occludens (ZO)-1, ZO-2, and junctional adhesion molecule (JAM)-1. Addition of exogenous polyamine spermidine reversed the effects of DFMO on [Ca2+]cyt and E-cadherin expression and restored paracellular ...
A. Glycoprotein contributions to mammary gland and mammary tumor structure and function: roles of adherens junctions, ErbBs and membrane MUCs. J. Cell Biochem. 96, 914–926 (2005). CAS PubMed Google Scholar Carraway, C. A. & Carraway, K. L. Sequestration and segregation of receptor ...
Lysosomes can modulate cellular signaling through two principles: first, through their involvement in the recycling of receptors to the plasma membrane by the endocytic pathway; second, lysosomes have emerged as the second largest intracellular storage organelle for Ca2+, a ubiquitous primary signaling m...
The importance of these signaling processes to cell biology makes it likely that manipulation of these processes will allow innovative therapeutic approaches to lung disease. 关键词: integrin extracellular matrix lung diseases signal transduction DOI: 10.1136/thx.51.9.956 被引量: 27 年份: 1996 ...
Recently, it has been shown that polyamines play an important role in the regulation of cell-cell interactions and are critical for maintenance of intestinal epithelial integrity. Both the function of polyamines in expression of adherens junction proteins and their possible mechanisms, especially in ...
05220 Function Adherens junction Pathways in cancer Cell cycle Focal adhesion Protein processing in endoplasmic reticulum Ubiquitin-mediated proteolysis Oocyte meiosis Neurotrophin signalling pathway HTLV-I infection Progesterone-mediated oocyte maturation Lysosome PI3K–Akt signalling pathway Chronic myeloid ...
(ITGA4) Downregulated IL-3 CSF2 CCL3 CEBPA LAT2 Function Biological process Transcription factor, cytokine receptor, anti- inflammatory signal, Adherens junction Cyclin-dependent kinase inhibitor Anti-apoptotic signal Transcriptional regulation, inflammation, cell adhesion Cell cycle, stem cell maintenance ...
demonstrated a dysregulation of E-cadherin and ß-catenin functions leading to partial disruption of adherens junctions [47]. A cooperation of E-cadherin and EpCAM in epithelial adhesion regulation is further supported by work in zebrafish, where EpCAM knockout impaired the integrity of the skin...
Microbe-associated molecular patterns NOD 1: Nucleotide oligomerization domain 1 NTA: Nanoparticle tracking analysis pEVs: Probiotic extracellular vesicles PEG: Polyethylene glycol PRR: Pattern recognition receptor TJ: Tight junction tRPS: Tunable resistance pulse sensing References...