Also, these skins made from knockdown cells have a significantly higher intensity of adherens junctions even in the basal layer compared to the wild type epidermis. We confirmed these results in vivo, in skin samples taken from genetically modified mouse carrying the JNK knockout genes. Similar ...
Adherens junctions are essential for the development and physiology of epithelial tissues. The Drosophila embryo is an excellent model for understanding adherens junction assembly, maintenance, and regulation during tissue development. Here, I review our current state of knowledge in this model system. ...
Adherens junctions (AJs) and the cadherin–catenin complexes at their core are therefore the subjects of intense research. Recent work has greatly advanced our understanding of the molecular organization of AJs and how cadherin–catenin complexes engage actin, microtubules and the endocytic machinery....
However, when cell junctions are present, both N-Cad and Cx40 traffic to the cell-cell interface (red arrowheads). Note: inflow cells form junctions in culture, but they tend to show disrupted morphology (blue arrowheads). Scale bars, as indicated in panels. (B) Representative images of N...
Biomedical engineering Adherens junctions in epithelial cells and in bioengineered tissues STATE UNIVERSITY OF NEW YORK AT BUFFALO Stelios T. Andreadis RanganathanAishwaryaRecently it was demonstrated that JNK acts as a switch, signaling adherens junction formation. Inhibition of JNK chemically by SP600125...
Andreadis, JNK regulates compliance-induced adherens junctions formation in epithelial cells and tissues, J Cell Sci, 126 (2013) 2718-2729.You H, Padmashali RM, Ranganathan A, Lei P, Girnius N, Davis RJ, Andreadis ST. 2013. JNK regulates compliance-induced adherens junctions formation in ...