Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease characterized by a heterogeneous tumor immune microenvironment (TIME). Tumor-associated macrophages (TAMs) constitute the major innate immune population in the TIME where they fac
The impact of neighborhood-level deprivation on epigenomic gene expression and lung cancer mortality has yet to be explored. This study aimed to assess the association between neighborhood-level deprivation and lung cancer mortality within the context of the U.S. health care system, as well as ...
The elderly' rights to life are flagrantly violated.U.S. politicians have followed the natural law of "selecting the superior and eliminating the inferior," declaring that "the elderly could sacrifice for the country" and that "the national economy is more important than the lives of the elderl...
Lung cancer is a leading cause of cancer deaths and imposes an enormous economic burden on patients. It is important to develop an accurate risk assessment model to determine the appropriate treatment for patients after an initial lung cancer diagnosis. The Cox proportional hazards model is mainly ...
Cancer, ranked as the second leading cause of mortality worldwide, leads to the death of approximately seven million people annually, establishing itself as one of the most significant health challenges globally. The discovery and identification of new a
has the potential to induce a long-lasting immune response, providing a durable and effective treatment option for cancer patients. The ability to specifically target cancer cells that overexpress certain antigens highlights the potential of vaccinations against TAAs or TSAs in cancer immunotherapy [4...
How to construct high-quality Chinese medical ontologies without overburdening medical experts is a challenging problem, and there is still a lack of suitable engineering methodologies that can be widely adopted. We refer to ontology building methods such as UPON [17], UPON Lite [18], and NeON...
Identifying pathogenic variants from the vast majority of nucleotide variation remains a challenge. We present a method named Multimodal Annotation Generated Pathogenic Impact Evaluator (MAGPIE) that predicts the pathogenicity of multi-type variants. MAG
ST has been widely used in the study of lung development and respiratory disease mechanisms due to the great interest in the molecular structure of the respiratory system. This section summarizes the emerging applications of the respiratory system, such as lung development, lung atlas, lung cancer,...
China is the world's largest developing country, with a population of 1.4 billion. In addition to its weak foundations and uneven development, the nation had long been plagued by poverty at a scale and a level of severity that has rarely been seen anywhere else in the world. As a result...