We compared the healthcare experiences and health outcomes of cisgender autistic (n = 1094), transgender/gender diverse autistic (n = 174), and cisgender non-autistic adults (n = 1295) via an anonymous, self-report survey. All individuals whose sex assigned at birth did not m...
Some argue that if we accept that trans identification is non-pathological, it does not require exploration, just as there is generally no need to explore the psychological formation of cisgender identities. It has been pointed out that this argument does not hold, as it is based on a ...
First of all, it is worth noting that when sex assigned at birth was referred, the terms "male" and "female" are used. When referring to gender identity, the terms "man", "women" and "gender diverse" are used. However, for the sake of clarity, the terms "cisgender man" and "cis...
Enhancers are key cis-acting elements that regulate the spatiotemporal expression of genes [1]. Enhancers are linear distal noncoding regions that stimulate transcription via long-range cis-chromatin interactions independent of their genomic orientation. In addition to typical enhancers (TEs), the genom...
Furthermore, computational approaches to solve "splicing codes" (e.g [3, 4]) are mainly focused on genome-wide prediction of cis-regulatory elements. Validation of results and inferences from these approaches still requires slow and expensive low-throughput approaches. Another limitation of current ...
Functional meaning of mutationsPersonalized therapyMutation searchMutation functional classesDespite its apparently simple genetics,cystic fibrosis(CF)is a rather complex genetic disease.A lot of variability in the steps of the path from the cystic fibrosis transmembrane conductance regulator(CFTR)gene to ...
In an exploratory study, investigating the use of these fields in ClinicalTrials.gov, potential confusion in the meaning of the terms “IPD” and “sharing”, and inconsistent responses were found in a qualitative analysis [2]. ClinicalTrials.gov added additional subfields to the IPD Sharing ...
The robustness of the conclusion was determined by assessing the consistency of the results of the NMA effect size (SMDs and 95% CIs) and SUCRA probabilities before and after conducting sensitivity analyses. Publication bias and grade of evidence We used a comparison-adjusted funnel plot and Egger...
The barcode counts obtained from RNA and DNA extractions are a noisy representation of the underlying activity. They are not just affected by sequencing depth, but also altered by various biological and experimental processes. The counts are prone to overdispersion, meaning there is greater variabilit...
The intrinsic frequency has the meaning of wave frequency in the reference frame moving with the local wind. For definiteness, we assume thatm > 0 whenm2 > 0 and Imm > 0 whenm2 < 0. In upward- and downward-propagating waves, vertical displacement of fluid particles is ...