According to a first aspect of the present invention, a method is provided for detection and quantification of a lipid profile in a blood sample, wherein the method comprises the step of: i) sample preparation, ii) detection by mass spectrometry of lipids in said sample, iii) identification ...
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Multiple studies have shown that more diverse and multi-ancestry GWAS can improve the predictive power and transferability of PGS, likely because the effect sizes of the true causal variants are shared across ancestry groups [117]. For example, a recent study of blood lipid levels showed that PG...
Likelihood ratio test was performed to compare the base model to the combined model, as well as to compare the multimarker panel to the combined model. DeLong test was used to compare between base model and multimarker panel. The AUC for the base model was 0.833 (sensitivity = 76.54%...
Additionally, conducting blood tests on an empty stomach within 2 h of morning collection enhances the accuracy of lipid level measurements by minimizing the impact of non-fasting conditions and freeze-thaw cycles. Nonetheless, limitations to the study exist. First, the study did not consider ...
Blood lipid concentrations are key CVD risk factors, and thus, lipid-lowering medication is an essential treatment option to prevent CVD. Diabetes is another major risk factor for CVD, as over 500 million individuals worldwide have diabetes. In particular, individuals with type 1 diabetes develop ...
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Peripheral blood mononuclear cells IL-2: Interleukin-2 p-MLKL: Phosphorylated MLKL SDS: Sodium dodecyl sulfate CDCA: Chenodeoxycholic acid DEGs: Differentially expressed genes SPEM: Spasmolytic polypeptide-expressing metaplasia CNV: Copy number variant ECs: Endothelial cells VECs: Vascular end...
Lipid accumulation in ccRCC cells is VHL/HIF-2α dependent, and downstream molecules of this signaling pathway, APOL1 was upregulated and predicted poor prognosis in ccRCC To dissect the mechanism of lipid deposition in renal cancer cells, we first evaluated the ability of a panel of three VHL...
Blood samples collected at the end of the experiment were allowed to coagulate for 30 min at room temperature, before centrifugation at 1500gfor 10 min. The serums were removed and stored at − 80 °C until further use. Serum I-FABP, lipopolysaccharide-binding protein (LBP), and IL-6...