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317) from snRNA-seq, coloured by annotated cell type. Data are shown after quality control and batch correction.c,d, Volcano plot representing MAST-based single-cell differential gene expression results (see section on ‘Single-cell differential gene expression’) of microglia...
=0.0027). Furthermore, another rare missense variant was recently shown to have a large impact on blood pressure in a large meta-analysis [78]. RBM47 encodes an RNA-binding protein essential for post-transcriptional modification of the apoB mRNA in particular. This modification creates a ...
Furthermore, a previously unknown pool of blood stem cells has been identified that is capable of restoring blood production when bone marrow stem cells are depleted. A new drug for multiple sclerosis: A new multiple sclerosis (MS) drug, which grew out of the work of UCSF (University of ...
Results Lipid accumulation in ccRCC cells is VHL/HIF-2α dependent, and downstream molecules of this signaling pathway, APOL1 was upregulated and predicted poor prognosis in ccRCC To dissect the mechanism of lipid deposition in renal cancer cells, we first evaluated the ability of a panel of th...
Self-report of a previous clinical diagnosis or a random blood glucose test were used to determine the diabetes status of participants in the study. The criteria defined by the American Diabetes Association (ADA) in their “standards of medical care in diabetes—2010”1 was used to classify dia...
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Results The potential for game-changing biochemical discoveries through mass spectrometry-based (MS) untargeted metabolomics and lipidomics are predicated on the evolution of more confident qualitative (and eventually quantitative) results from research laboratories. RMs are thus critical QC tools to be ab...
Next, we use these data to select genes associated with blood lipids that encode druggable targets and test the effects of these drug targets on CHD using “drug target MR” in two independent datasets. In parallel, we investigate if the genetic associations with each lipid sub-fraction and ...
Degrading pathogenic proteins by degrader technologies such as PROTACs (proteolysis-targeting chimeras) provides promising therapeutic strategies, but selective degradation of non-protein pathogenic biomolecules has been challenging. Here, we demonstrate