5A) is a protein complex that forms a platform for K63-linked ubiquitylation and recruitment of downstream factors like Tak1 (TGF-β activated kinase 1), Tab2 (TAK1-associated binding protein 2), and key (kenny, a.k.a. NEMO). Analogous complexes function within the mammalian TLR (Toll-...
The good interpretability of SPACE in representing spatial domains, combined with this consistency, forms the foundation for its superior performance. SpaDo enables multi-slice spatial domain detection We illustrated the utility of SpaDo to detect spatial domains that can be comparable across multiple ...
This article focuses on the innovative forms and variants of these technologies. Imaging-based ST strategies Image-based ST technologies include fluorescence in situ hybridization (ISH)- and in situ sequencing (ISS)-based methods. The advent of high-resolution microscopy and single-molecule ...
The 1970s were an important time in the modern history of biomedicine. This is the period when the first eukaryotic genes were cloned (Morrow et al.1974), and the Richards lab was among the first to apply modern molecular biology methods to the study of parasites. I spent almost all my ...
There was no significant difference in the rate of major segmental deformities or cytoplasmic residual droplets between the two groups (P > 0.05 [Table 2, Fig. 4]). Sperm DFI analysis After SCD staining, the sperm head forms a halo of different thickness, where no halo or only a ...
Single-cell RNA sequencing (scRNA-seq), a technology that analyzes transcriptomes of complex tissues at single-cell levels, can identify differential gene expression and epigenetic factors caused by mutations in unicellular genomes, as well as new cell-specific markers and cell types. scRNA-seq plays...
Plant somatic cell regeneration includes organogenesis and somatic embryogenesis pathways, which represent forms of fertilization-independent development. Plant somatic embryogenesis is a process in which somatic cells of a variety of tissues are cultured in vitro to undergo de-differentiation and then re-...
In addition to the role of protein-coding genes as key regulators of plant immunity, increasing evidence indicates the importance of non-coding RNAs (ncRNAs) in plant immune responses. Depending on their mode of biogenesis and their functions, ncRNAs have evolved into various forms that include mi...
Open Source and Open Data aim at ensuring that materials such as questionnaires, forms, procedures, collected data, metadata, and source code are shared to foster replication studies, increase data re-use, and facilitate the peer-reviewing process [14, 15]. Indeed, reviewers have the material ...
[11, 23, 42], several recent findings coincide with our results and indicate that it is not the multiple copies of the genes, but rather the functional forms of the THCAS and CBDAS proteins that play a key role in the synthesis of tetrahydrocannabinolic acid (THCA) and cannabidiolic acid...