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Traumatic brain injury (TBI) is one of the most common causes of morbidity and mortality of both young adults of less than 45 years of age and the elderly, and contributes to about 30% of all injury deaths in the United States of America. Whereas there has been a significant improvement ...
Enhanced performance and the autonomy of perception form the basis for the Enhanced Perceptual Functioning model (EPF) of autistic cognition [19]. This model proposes that the superior performance of autistic individuals in multiple basic perceptual tasks results from strong encoding mechanisms in a sub...
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2024, 32(S1): O7 Background The devastating consequences of traumatic brain injury (TBI) can include brain herniation secondary to increased intracranial pressure (ICP). In the pre-hospital setting, clinical signs such as fixed dila...
Following total body irradiation (TBI) preconditioning, there was an upregulation of various inflammasome components, containing NLRP1 and NLRP6, with IL-1β and IL-18 functioning as key mediators of inflammatory damage. Caspase-1 inhibitors demonstrated efficacy in reducing inflammation and promoting ...
Neurological damage frequently arises from a range of traumatic injuries and disorders, including trauma [1], ischemia and hypoxia [2], and infection [3]. Within this spectrum of injuries, traumatic brain injury (TBI), spinal cord injury (SCI), and stroke are classified as CNS injuries. These...
Intestinal stem cells (ISCs) are responsible for intestinal homeostasis and are important for the regeneration of damaged intestine. We established an ionizing radiation (IR)-induced intestinal injury model and observed that Gelsolin KO mice had increase
We excluded patients who presented (1) clinical diagnosis of dementia; (2) probable dementia, with a MoCA score equal to or less than 18 points [66]; (3) neurological disorders, including stroke or traumatic brain injury (TBI) in the past 12 months; (4) history of mental or psychiatric...
Traumatic brain injury (TBI) is a key contributor to global morbidity that lacks effective treatments. Microbial infections are common in TBI patients, and their presence could modify the physiological response to TBI. It is estimated that one-third of t
[67]. In light of the central role of C3 and downstream complement activation fragments in the pathophysiology of TBI, much emphasis has been recently devoted to elucidating therapeutic aspects of C3 convertase inhibition, in various experimental model systems [68–72]. Genetically engineered mice, ...