The development of the cortex is a delicate balance between proliferation, differentiation, and migration of neural progenitors (NPs). Throughout developmental process, various cellular mechanisms ensure that NPs differentiate into the correct cell subtypes, migrate to their correct regions, and form the...
According to the half r2 value of the six breeds, we considered 10 kb as the SNP site-linked distance for the signal detection window. Genome-wide selective signature detection To better mine the functional areas closely related to egg-laying traits, we assigned three breeds (HY, ZE, SC, ...
Because of the female heterogamety in all candidate SNP loci, we report for the first time that pistachio has a ZZ/ZW sex determination system. As the reported female-to-male segregation ratio is 1:1 in all known segregating populations and there is no previous report of super-female ...
2g). Similarly, full-length coverage with Smart-seq3xpress resulted in significantly (2–5-fold) increased read support over exon–exon and exon–intron splice junctions, which form the basis for RNA velocity inference16 (Fig. 2h). To perform a direct comparison of cluster granularity, we ...
1). In their simplest form, deletions and inversions were found to be the most common SV types, while consistent with other PCa studies, we observed a low frequency of insertion events (Additional file 1: Fig. S2). Only 15 tumours (8.3%) presented with at least one insertion, which may...
A total of 7,191 metabolites were identified using non-targeted metabolomics; these were integrated to form a chicken serum metabolite public reference dataset that can provide a reference for future chicken metabolomics studies. The identification of unknown metabolites is an urgent problem in ...
, through weakening of the ECS-editing site interaction to form poorer duplex RNA substrates for ADARs, could titrate in the edited form of the protein to the least advantageous level, or even an undetectable level. Figure 7 Phylogeny of RNA editing and duplicated exons of nAChR subunit alpha6...
The first step of data analysis is to assess and clean the raw sequencing data, which is usually provided in the form of FASTQ files [32]. Quality control visually reflects the quality of the sequencing and purposefully discards low-quality reads, eliminates poor-quality bases and trims adaptor...
A recent publication documented the somatic NRF2 gain-of-function mutations in cancer [112]. However, mutation of either Keap1 and NRF2 in RCC is a very rare event (Supplemental TableS2) and the mutant cohorts were too small to form meaningful evaluation of the role of their mutations in RC...
(Ts/Tv) of 2.667 to 2.695 in each population, proving the high quality and validity of the SNP data. From the total SNPs, 84.24% were aligned to intronic and intergenic regions, whereas only 2.37% were located in the exons’ regions, and most of these SNPs were homozygous SNPs (69.23%...