These collagen fibers form fiber bundles, with the principal fibers being the most critical components. These fibers anchor the tooth by inserting into the cementum on one side and the alveolar bone on the other. Additionally, the principal fibers contain elastic fibers (oxytalan) [31], which ...
Fan et al. [14] have verified that migrasome formation is directly linked to the persistence and speed of cell migration. We observed that RAW264.7 cells leave long RFs during migration, and migrasomes form on the tip or branching point of the RFs through transmission electron microscopy ...
Photo crosslinking promotes the crosslinking of gelatin and methacryloyl anhydride under UV irradiation to form GelMA, resulting in the controlling the release or localization of therapeutic genes/growth factors, and improving gene therapy accuracy. Gelatin hydrogels exhibit good cell adhesion, ...
Two strategies have been proposed to overcome immune suppression: the disruption of TGF-β receptors on CAR-T cells and the engineering of CAR-T cells to express a dominant-negative form of the TGFβ receptor (TGFβRIIDN) into the CAR-T cell construct which allows the CAR-T cells to ...
Ferroptosis is a newly identified iron-dependent form of death that is becoming increasingly recognized as a promising avenue for cancer therapy. N6-methyladenosine (m6A) is the most abundant reversible methylation modification in mRNA contributing to tumorigenesis. However, the crucial role of m6A modi...
Ferroptosis is a distinct form of programmed cell death characterized by excessive production and accumulation of reactive oxygen species (ROS) and increased lipid peroxidation driven by iron overload [6, 7]. Glutathione peroxidase 4 (GPX4), a key regulator of ferroptosis, suppresses lipid peroxidatio...
[80]. DNA origami is one of the greatest advancements in the core project of nanorobotics. A single-stranded DNA can be collapsed into a two-dimensional shape and eventually form a three-dimensional nanostructure, which can release its payloads upon binding with a specific cancer biomarker [81...
Additionally, these cells are able to form capillary structures on Matrigel, while mesenchymal cells isolated from adult sources (bone marrow and adipose tissue) cannot. Therefore, the selection of MSCs from fetal sources, such as the umbilical cord or amniotic membrane/fluid, can be an attractive...
However, prolonged activation causes severe tissue damage in the body and may induce pyroptosis, a highly inflammatory form of cell death characterized by cellular lysis and destruction [11]. More than ten types of inflammasomes have been identified currently, each intricately intertwined in the ...
There is compelling evidence demonstrating fibroblast exosomes induce colorectal cancer cells to exhibit stem cell characteristics, such as the ability to form spheres and grow tumors. They also increase the number of cancer stem cells in colorectal cancers by activating the Wnt signaling pathway. ...