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namely the ABCDE cluster and the PQR cluster. The autophosphorylation of the ABCDE cluster promotes the joining of DNA ends. After DNA-PKcs is activated by binding to the DNA-Ku complex, it undergoes autophosphorylation along with phosphorylation of other substrates such as XR...
Pyoverdine (PVD) is an NRP belonging to the class of siderophores and produced by fluorescentPseudomonas.PVD is secreted by the cell in the extracellular medium where it chelates iron with very high affinity (1032M−1) [26]. Since iron is essential for sustaining life, siderophores represent ...
2]. The prognosis for GBM is poor, with a median survival of 12–15 months and a five-year survival rate of 6.9% [3]. The Stupp protocol, which comprises of concomitant radiation and chemotherapy, temozolomide (TMZ) to destroy cancer cells, is used as the first...
Protein surface electrostatics calculations were carried using Adaptive Poisson-Boltzmann Solver (APBS) [56], where an externally generated pdb (P) file with per-atom charge (Q) and radius (R) (PQR file) file was used to calculate the electrostatics. The parameters used were solvent and ...
In the last fifteen years, rapid progress has been made in delineating the cellular response to DNA damage. The DNA damage response network is composed of a large number of proteins with different functions that detect and signal the presence of DNA dama
(e.g., CXCR4, MMR9, MMR2, and TIMP1) further underscoring the interplay between plasticity and EMT [62]. CSCs also exhibit enhanced resistance to anoikis, a form of cell death triggered by detachment from the extracellular matrix. This resistance enables CSCs to survive within the ...
Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer subtype often treated with radiotherapy (RT). Due to its intrinsic heterogeneity and lack of effective targets, it is crucial to identify novel molecular targets that would increase RT efficacy. Here we demonstrate ...
GDCX cells notably showed more cells penetrance in the form of greater proportion of extending cells (Fig. 4e). Predictably, the histopathology of GDCX cells in the murine tumor was different from that of the wt-C6 murine glioma tumor; tissues stained with anti-DCX, anti-GFAP, and anti-...
PI3CA mutations are found in 4.4% of lung adenocarcinoma and 16% of squamous cell cancer. PI3CA amplifications are found in up to 40% of squamous cell lung cancer [53, 54]. PI3CA mutations also promote resistance to EGFR TKIs. PQR309 is a pan-PI3K, mTOR inhibitor. Its safety and ...