The PDB entries were classified according to the structures of the proteins in the complex. The classification system categorizes them in a two-tier system at the group and family levels. At the first level, proteins were sorted manually into eight groups by visual inspection using RasMol [7]...
To effectively develop novel pharmacological agents to regulate pGC-A, structural information is needed on its full-length form. The pGC-A monomer contains a peptide binding extracellular domain (ECD), a single helix transmembrane domain and an intracellular domain (ICD), which contains one protein ...
has emerged as a promising cell factory for biological production of lipids, carotenoids, and certain industrially relevant enzymes [2,3,4]. It is capable of accumulating high levels of internal storage lipids in the form of triacylglycerols (TAGs) from excess carbon when other nutrients such as ...
The fungal kingdom is one of the most diverse and oldest clades of the eukaryotic life, with an estimated 2.2–3.8 million species that play important roles in the terrestrial and aquatic ecosystems [1,2]. However, fungi have the lowest rate of description among the major eukaryotic groups [...
Column ‘X-Ray structure’ represent the crystallographic structures of ECD (PDB: 2CE852) and CD (PDB: 1T4520) of KIT. (B) Structure of the KIT CD (PDB:1T45) with missing KID, JMR N-term and C-terminal fragment as pointed lines. The tyrosine residues (Y) and the proteins that ...
IL-6 and gp130 form a complex with membrane-bound IL-6 receptor (mIL-6R), while in the trans pathway, they bind to the soluble form of IL-6 receptor (sIL-6R). In either case, the IL-6 receptor (IL-6R) signaling complex activates intercellular signaling involved in a wide range of...
PDZ domains are abundant protein interaction modules that often recognize short amino acid motifs at the C-termini of target proteins. They regulate multiple biological processes such as transport, ion channel signaling, and other signal transduction sys
Human IDO1 (hIDO1) is an α-helical dioxygenase protein containing a small N-terminal domain (NTD, residues 1–154) and a large C-terminal domain (CTD, residues 155–403) (PDB code: 5WMU, Fig. 4a). The CTD is made up of thirteen α-helices (G-S) and two 310 helices, four lon...
called viral enzymes, for a total of 16 non-structural proteins [3]. Subsequently, the non-structural proteins form a replication/transcription complex (RNA-dependent RNA polymerase), using the genomic RNA (+) as a model. The WHO clarified that there are a high number of mutations as more ...
Initially, the 3D structure of OA was obtained in “mol2” format from the China Traditional Medicine System Drug Database and Analysis Platform (TCMSP, https://old.tcmsp-e.com/tcmsp.php) [37], and then saved in “PDB” format using Pymol 2.5.7 (Portland, OR, US). The protein ...