Although it’s been known for over half a century that viral infection alters host cell metabolism, the mechanisms and consequences of virus-induced metabolic reprogramming have only begun to be studied in detail over the past decade (Fig.1). Viruses clearly rely on host cell machinery to propa...
such as mitochondrial poly(A) polymerase (MTPAP), PAP associated domain containing (PAPD)4, PAPD5, zinc finger, CCHC domain containing (ZCCHC)6, ZCCHC11 and terminal uridylyl transferase 1, U6 snRNA-specific (TUT1) [82], have been implicated in the generation of non-templated 3′ isomi...
The only exception to this observation consists of three Welsh Pony sequences which form a clade, although even here a fourth Welsh Pony sequence (Welsh_C Section B) falls outside this clade. These results represent strong evidence that many breeds do not have a single maternal origin and ...
While advances in molecular phylogenetics have increased the level of inference we can draw on trait evolution or species relationships, poorly resolved trees resulting from biological processes (e.g., ancient or recent hybridization, incomplete lineage sorting, introgression or rapid radiation) or system...
With the arrival of telomere-to-telomere (T2T) assemblies of the human genome comes the computational challenge of efficiently and accurately constructing multiple genome alignments at an unprecedented scale. By identifying nucleotides across genomes whi
The onset of clinical assisted reproduction, a quarter of a century ago, required the isolation of motile spermatozoa. As the indication of assisted reproduction shifted from mere gynaecological indications to andrological indications during the years, t
Necroptosis of macrophages is a necessary element in reinforcing intrapulmonary inflammation during acute lung injury (ALI). However, the molecular mechanism that sparks macrophage necroptosis is still unclear. Triggering receptor expressed on myeloid ce
of a potential repeating sequence. Based on this observation, we proposed two possible genomic configurations: (1) a master circular structure encompassing all three contigs (Fig.1C), and (2) an alternative configuration wherein contig1 and contig2 form two independent circles with contig3, ...
(the biotinylated form of TBE31) has been demonstrated to effectively and persistently promote the degradation of BACH1 by the E3 ligase FBXO22 (50-fold more potent than hemin), while TBE31 has no influence on BACH1 levels. TBE53 (but not TBE31) reduces breast cancer cell migration and ...
Overview of the RhizoMAP workflow. Imprinting membranes (PETE and GTTP) are placed on the roots of plants growing in the Rhizobox. After 48 h, membranes are removed and mounted on the MALDI target (MTP) plate using double-sided Cu tape. On-target chemical derivatization (OTCD) and MALDI ...