2022b. Metformin improves renal injury of MRL/lpr lupus-prone mice via the AMPK/STAT3 pathway. Lupus Sci Med. 9. Choi SC, Brown J, Gong M, Ge Y, Zadeh M, Li W, Croker BP, Michailidis G, Garrett TJ, Mohamadzadeh M, Morel L. 2020. Gut microbiota dysbiosis and altered tryptophan ...
Screening bacteria for rubber degradation by this screening process can be challenging when the identifying bacteria exhibit no obvious indications of reaction. Actinomycetes, such as Nocardia and Mycobacterium, as well as non-actinomycetes like Corynebacterium, do not form a transparent areas when ...
cells and form secondary vesicles, NO not only eases bacterial escape from the secondary vesicles but also hinders the fusion of phagolysosomes with secondary vesicles, both of which simplify cell-to-cell infection; thus, NO acts as a pathogen helper to accelerate the spread of infections [30]...
Pyroptosis, as a form of programmed cell death, plays a crucial role in initiating and advancing the inflammatory response through an amplification loop of inflammation and necrosis [14]. In vivo experiments, we observed that OPN inhibitor can significantly reduce the expression of NLRP3 in the lu...
Despite being a less common form of scabies, it is a serious, debilitating form of the disease, which is largely neglected [5]. It is well established that mite antigens that diffuse into the dermis can trigger cellular and humoral immune responses and disturb the balance between type 1 ...
The inflammatory responses from synovial fibroblasts and macrophages and the mitochondrial dysfunction in chondrocytes lead to oxidative stress, disrupt extracellular matrix (ECM) homeostasis, and accelerate the deterioration process of articular cartilage in osteoarthritis (OA). In recent years, it has been...
High mobility group box 1 (HMGB1) is a nonhistone chromatin-associated protein that has been widely reported to play a pivotal role in the pathogenesis of hematopoietic malignancies. As a representative damage-associated molecular pattern (DAMP), HMGB1 n
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3B-H), artemisinin contains multiple carbon rings and is able to form strong hydrophobic interactions with amino acids VAL-249, VAL-253, MET-250, PHE-254, LEU-267, MET-231, PHE-228, PHE-270, reflecting its strong hydrophobicity. Artemisinin also has strong hydrogen bonding interactions and ...
formins. This section provides brief overviews of the ways ABI1 regulates actin cytoskeleton machineries. ARP2/3 complexes ARP2/3 is activated by nucleation promoting factors such as the WAVE regulatory complex (WRC), a pentameric protein complex comprising ABI1, WAVE2, SRA1/CYFIP1, BRK1, ...