Destruction of full-length androgen receptor by wild-type SPOP, but not prostate-cancer-associated mutants. Cell Rep 2014; 6: 657–669. 45. Geng C, Rajapakshe K, Shah SS, Shou J, Eedunuri VK, Foley C et al. Androgen receptor is the key transcriptional mediator of the tumor suppressor...
Full size image This result suggests that TC-DPC repair represents the predominant DPC repair pathway in non-replicating or differentiated cells. To test the contribution of TC-DPC repair in non-replicating cells, we performed Alamar-Blue-based survival assays, which showed that non-replicating CSA...
Download: Download full-size image Fig. 2. Depletion of CDT2 inhibits melanoma cell proliferation through the induction of rereplication and senescence (see also Figures S3 and S4). a. Impact of CDT2 depletion by siRNA on the proliferation of DM93 melanoma cells. Data represent the average of...
Each method was repeated three times and the order of testing was randomised between subjects and testers.Results24 full sets of data were available for analysis. In terms of intertester reliability the ICC values ranged form 0.825 to 0.854. For intratester reliability ICCs were 0.889 for tester...
S12A). This conformation has previously been described as the dumbbell form, for free (78) and ssDNA-bound A3G (79). Download: Download high-res image (326KB) Download: Download full-size image Fig. 5. Structural heterogeneity of the A3G-Vif-CRL5-CBFβ complex. A, distribution of ...
The core domain-truncated TOP1 and C- terminus-truncated TOP1 failed to bind DCAF13, while the TOP1 core domain alone was able to bind DCAF13, albeit not as strongly as the full-length TOP1 (Fig. 7b). This is presumably due to its lost ability to form TOP1ccs. These results ...
(Fig.7a). The core domain-truncated TOP1 and C-terminus-truncated TOP1 failed to bind DCAF13, while the TOP1 core domain alone was able to bind DCAF13, albeit not as strongly as the full-length TOP1 (Fig.7b). This is presumably due to its lost ability to form TOP1ccs. These ...