This signature serves as a valuable reference for further exploring the role of tryptophan metabolism in renal cell carcinoma and for the development of clinical applications based on this metabolic pathway.Introduction Renal cell carcinoma (RCC) is the most prevalent form of kidney cancer, ranking ...
juvenile myoclonic epilepsy (JME), and GGE with tonic–clonic seizures (TCS) (GGE-TCS), is genetically influenced with a two- to four- fold increased risk in the first-degree relatives of patients. Since large families with GGE are very rare, international studies have focused on sporadic...
Second hand smoking (SHS) increases the risk of chronic physical conditions in adults, while also posing severe health risks (e.g., sudden infant death syndrome) to children [1,2,3,4,5]. The 2019 Global Burden of Disease Study estimated that exposure to SHS contributed to 1.3 million prem...
Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid peroxidation, is governed by molecular networks involving diverse molecules and organelles. Since its recognition as a non-apoptotic cell death pathway in 2012, ferropt
[4]. In the nucleus, Nrf2 binds with Maf protein to form heterodimers, competitively displacing BACH1 from ARE-binding sites. This, in turn activates the antioxidant, anti-inflammatory and neuroprotective cascades. Clearly, downregulation of BACH1 would lead to activation of Nrf2-associated pathways...
These mutations may produce aberrant protein that can either antagonize DNA-binding activity of wild-type proteins or form inactive dimers with wild-type proteins, impairing wild-type protein function in both situations. Co-transfection assays with mutant and wild-type PITX3 could not, however, ...
In addition, many studies have attempted to modify engineered CAR T-cells to induce endogenous antitumor immunity and thus reshape the TME. One study designed a novel CAR T-cell (RN7SL1 CAR T-cell) that secreted non-coding RNA RN7SL1 in the form of extracellular vesicles (EVs), which wou...
Intellectual disability (ID) can be caused by non-genetic and genetic factors, the latter being responsible for more than 1700 ID-related disorders. The broad ID phenotypic and genetic heterogeneity, as well as the difficulty in the establishment of the
(1) with each other in the form of regulatory networks; and (2) with other kinds of data. Regulatory hypotheses can be integrated with each other to identify regulatory networks of transcription factors, including regulatory loops and, for instance, hypothesize that transcription factor A regulates...
We hypothesized that this genetic cause of a Mendelian form of ASD may be part of a family of genes that could predispose to the genetically complex idiopathic forms of ASD. To pursue this we tested the 10 CCGs that encode the largest subunits, α1, of 10 distinct Ca2+ channels. ...