The weighted mode estimate may also be used even when the majority of the SNPs are invalid instruments so long as the SNPs that form a cluster of homogenous results are valid [48, 52]. Finally, we adopted an MR-Egger analysis to evaluate evidence for the presence of horizontal pleiotropy....
The Maf proteins (Mafs) belong to basic leucine zipper transcription factors and are members of the activator protein-1 (AP-1) superfamily. There are two subgroups of Mafs: large Mafs and small Mafs, which are involved in a wide range of biological processes, such as the cell cycle, prolif...
between the locus of immunoglobulin heavy chain (IgH) on chromosome 14q32 and one of the several MM-related oncogenes. Such translocation frequently involves the MAF bZIP transcription factor (MAF), the fibroblast growth factor receptor 3 (FGFR3), the multiple myeloma SET domain (MMSET), and ...
After their production in the colon, only a small portion is present in the intestine in the unionized form that can cross the epithelial barrier directly, whereas approximately 80–90% of short-chain fatty acids are present in an ionized form and require specific transporters for their ...
It shouldn’t remove information of cellular identity to form “average cells” or collapse different cell types or states into one. Second, the network should be robust to the presence of different cell types in hq and lq data or an imbalance in their relative ratios. It should not, for ...
2 in the form of a Manhattan map and volcano plot. In the sensitivity analysis with additional MR approaches (MR Egger, weighted median, weighted mode, and simple mode), the direction of causality of significant findings were all in concordance with the primary conclusions (Additional file1: ...
It is worthwhile noting that for both SNP, neighbouring loci failed to exhibit significant association signal to form broad association peaks. This raises the possibility the genomic location of the two peak SNP may not be correct, and suggests caution is required with regard the involvement of ...
CTSA has been associated with an autosomal recessive form of Galactosialidosis (OMIM: 613111), for which intellectual disability is a common symptom. We only had two multiplex families in the setting of parental consanguinity in our cohort (each with three affected siblings). While we expected ...
We combined the original data from 19 blood samples (HY and LH) with 36 database resequencing data (ZE, ZD, SC, and ST) to form the 55 samples (Table 1) in the study. Based on the sequencing results, the average sequencing depth reached 11.75X, with the min and max being 8.07X an...
Ferroptosis, a novel form of iron-dependent lipid peroxidation mediated regulated cell death (RCD) in cellular membranes, has recently been shown to functions as a dynamic tumor suppressor in cancer development, highlighting regulating ferroptosis can be utilized as an interventional target for tumor tr...