TCDCA is the precursor of TUDCA, and the two form an isomer pair. Importantly, bear bile contains a relatively high content of TUDCA (23–40%), while the content of TUDCA in other animals’ bile is very low (< 1%) [50,51,52]. Interestingly, the content of TCDCA in the bile of...
Lysosomes can move towards the plus or minus ends of microtubules. The movement towards the plus end of microtubules is mediated by kinesins, of which the best characterized is kinesin-1, which is composed of two heavy chains (KHC) and two light chains (KLC). BORC can associate with ...
Understanding tumor cell heterogeneity and plasticity is crucial for overcoming drug resistance. Single-cell technologies enable analyzing cell states at a given condition, but catenating static cell snapshots to characterize dynamic drug responses remai
Understanding of the autophagic machinery has advanced; however the primary source of the phospholipid bilayer that creates the autophagosome membrane has remained unclear [2, 3]. The difficulty in identifying the origin of cellular material donated to form autophagosome membranes reflects the inability ...
KLC designed the original web pages, set up the Btau_2 Gbrowse, and created a script to show BLAST hits on GBrowse. DCV modified the code for formatting BLAST output to retrieve data from the Chado database instead of a MySQL database. AV assisted in trouble shooting system compatibility ...
KLC, HCH and MFC proposed the study design. KLC, HJL, and BCL participated in data collection. KLC and PHL performed statistical and genetic analysis. HCH performed lipids and laboratory measurements and quality control. KLC and MFC conceived of the study, and participated in its design and coo...
Circular RNAs (circRNAs) have recently emerged as a new form of non-coding RNA in a wide variety of organisms [1]. Different from the traditional linear RNAs, they are special endogenous RNA molecules that are predominantly formed by 3′-5′ head-to-tail ligation in a backsplicing reaction...
Two experienced radiologists (with 10 years of experience in breast imaging diagnosis) who were blinded to the histopathological results independently performed the data analysis. Before parameter calculation, a nonlinear registration framework utilizing the Free Form Deformation algorithm was used to ...
(KLC) uses orthographic and shallow linguistic features (POS, lemma, stem) of the tokens located at the left and right (window size of 2) of the candidate entities (EHD3 and MDD).d)The global context kernel (KGC) is based on the assumption that an association between two entities (in ...
KLC participated in the design of the study and manuscript process. JE, CM, PF, PC participated in the design of the study. PN conceived of the study, supervised the coordination of the study, and helped to draft the manuscript. All authors read and approved the final manuscript....