Microglia, the resident immune cells of the brain, play a crucial role in maintaining homeostasis in the central nervous system (CNS). However, they can also contribute to neurodegeneration through their pro-inflammatory properties and phagocytic functions. Acute post-operative cognitive deficits have ...
Functional enrichment analyses of AD/SID-related genes Using the list of input genes for the molecular landscape that we derived from the MAGMA and FUMA analyses, we performed functional enrichment analyses with Ingenuity Pathway Analysis [46] (IPA,QIAGEN Inc., https://www.qiagenbioinformatics.com...
Despite its important endogenous role and therefore promising drug target, the predominant therapeutic focus is limited to hereditary angioedema (HAE), a rare disease affecting 1 in 50,000 to 100,000 people [15]. However, recent research has demonstrated the relevance of the KKS in numerous other...
Method: The prototype formulations of micropellets were prepared using drum pelletizer at 300 rpm. Percentage of water in binding liquid, i.e. IPA, is varied from 95 to 99% and the effect on various parameters, such as particle size, entrapment, bulk density and particle shape, were ...
(IPA) drug in a resistant starch (RS) and solidified crosslink structure between Ca2+and alginate via a capillary microfluidic electrospray method, followed by coating with chitosan via spontaneous electrostatic interactions (between chitosan and alginate), which minimizing the leakage of IPA agents [...
There is increasing evidence that Parkinson’s disease (PD) might start in the gut, thus involving and compromising also the enteric nervous system (ENS). At the clinical onset of the disease the majority of dopaminergic neurons in the midbrain is alread
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) can be used to treat heart diseases; however, the optimal maturity of hiPSC-CMs for effective regenerative medicine remains unclear. We aimed to investigate the benefits of long-
[IPA] and 3-indolelactic acid [ILA] in the untreated HIV/TB co-infected group when compared to the healthy controls). Tryptophan was decreased in all patient groups relative to healthy controls, and this was most pronounced in the untreated co-infected group although not statistically ...
Thailand faces a significant burden in terms of treating and managing degenerative and chronic diseases. Moreover, incidences of rare diseases are rising. Many of these—such as diabetes, cancer, and inherited inborn metabolic diseases—have no definite
In recent years, studies of traditional medicinal plants have gradually increased worldwide because the natural sources and variety of such plants allow them to complement modern pharmacological approaches. As computer technology has developed, in silico approaches such as virtual screening and network ana...