Full size image Despite an overall high structural resemblance between NiV prefusion F and the divergent LayV (RMSD = 1.8 Å) and MojV F (RMSD = 2.6 Å) structures, there are some notable differences. Comparison of the trimers reveals a shift in the major outward facing...
Here, we present the structures of the full-length BipA from Escherichia coli in apo, GDP-, and ppGpp-bound forms. The crystal structure and small-angle X-ray scattering data of the protein with bound nucleotides, together with a thermodynamic analysis of the binding of GDP and of ppGpp ...
Full results of this trial are awaited with interest. A randomised phase II trial of enzalutamide ± AZD5363 in patients with mCRPC (RE-AKT, NCT02525068) is currently recruiting. Similarly, in ER + ve breast cancer, hormone resistance is also associated with an increased dependence on PI3K/...
You could say a Hazy IPA is a form of wheat beer. This is because not all Hazy IPAs or beer will use wheat as an ingredient. And not all wheat beers are hazy. Some are filtered like the Kristallweizen, for example. What Makes a Beer a Hazy IPA? Fruit-forward hops, low-flocculati...
Here we show that Henipavirus TAIL domains are also disordered in the context of full-length nucleoproteins. We also report the cloning, purification, and characterization of the C-terminal X domains (PXD) of Henipavirus phosphoproteins. Using isothermal titration calorimetry, we show that N ...
It was my first Brew using Brun-water to dial in the water chemistry and mash ph, and the resulting beer was nothing short of life-changing. Almost literally so. I called three brewing friends to stop in and try it the first night on tap, and they showed up the next two nights in ...
Similarly, the RBP ectodomain or the full-length HeV-RBP and NiV-RBP form tetramers in solution by forming disulfide bonds in the stem region, and head domains are monomers in solution (Bowden et al., 2010; Maar et al., 2012). A negative-stain electron microscopy (EM) study of NiV-...
Accordingly, we were interested in determining whether kynuric acid was present in an unbound form in plasma. Thus, five randomly selected untreated HD patient plasmas were obtained, and were extracted as before the protein pellet was saved for later use. The supernatant of the plasma was ...
7. The method according to claim 1, wherein the VL has the amino acid sequence of SEQ ID NO: 4, and wherein the VH has the amino acid sequence of SEQ ID NO: 3. 8. The method according to claim 2, wherein the antibody is a full-length IgG antibody. 9. The method according to...
In a previous study, we reported that in henipaviruses, the N-terminal domain of the phosphoprotein and the C-terminal domain of the nucleoprotein (N(TAIL)) are both intrinsically disordered. Here we show that Henipavirus N(TAIL) domains are also disordered in the context of full-length ...