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However, there are important differences in the form of the model and the underlying assumptions that are worth mentioning here. Let us denote the intensities for each probe by PMijn and MMijn, where n represents the probe sets or genes, i represents the array or sample, and j the probe ...
However, there are important differences in the form of the model and the underlying assumptions that are worth mentioning here. Let us denote the intensities for each probe by PMijn and MMijn, where n represents the probe sets or genes, i represents the array or sample, and j the probe ...
Glioblastomas (GBMs), the most aggressive and incurable primary brain tumors, form a very dynamic ecosystem, in which heterogeneous tumor cells reciprocally interact with various cells of the TME [2]. The brain TME includes endothelial cells, pericytes, astrocytes, neurons, oligodendrocytes, and ...
With the completion of SC differentiation, the expression of Gnao1 rose again, at which time the mature SCs began to wrap the axons and form myelin sheaths Full size image Endogenous Gnao1 alterations in SCs affect re-myelination, but Gnao1 in neurons not To assess the in vivo contribution ...
3b) form a highly conserved cluster of 18 genes. An Osiris cluster is thought to have originated already very early in the evolution of winged insects [4, 79]. Astonishingly, despite this ancient conservation in genomic organization, the Osiris genes have no Gene Ontology terms associated ...
Functional selectivity of Gγ subunits has also been reported [24–26]; deletion of the Gng3 gene leads to increased susceptibility to seizures in mice with significant reductions in Gβ2 and Gαi3 subunit levels in certain brain regions [25], whereas knock-out of the Gng7 gene is ...
. these currents take the form of two large-scale vortices on the day side of the earth, one counterclockwise in the northern hemisphere and the other clockwise in the southern hemisphere. they generate magnetic fields that can be sensed on the ground, where they reach a few tens of nt, ...
Cas9 binds a dual crRNA (CRISPR RNA)-tracrRNA (trans-activating RNA) molecule, or an artificial single-guide RNA (sgRNA) to form a functional complex that acts as an RNA-directed DNA endonuclease capable of generating a DNA double-strand break (DSB) within the target sequence [6, 7]. ...
Whether it does so as a form of retaliatory chemical warfare or as a means of inter-species communication is open to speculation. Antibiotics as signalling molecules? The production of metabolites with antibiotic activity is a widespread trait of soil microorganisms, and must confer some evolutionary...