All patients and/or their family members were informed of the usage of the sample and signed the informed consent form. The human protocols were implemented strictly on the basis of the Ethical Guidelines of the Declaration of Helsinki. They were approved by the ethics committee of The Second ...
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Changes in the fecal metabolome after allo-HSCT.AThe concentration of short-chain fatty acids (butyrate, propionate, and acetate) is reduced after allo-HSCT. ND: not detected.BOrthogonal partial least squares discriminant analysis (OPLS-DA) shows global differences in the metabolome of pre- (pre)...
as well as transcriptional/epigenetic alterations, all leading to excessive proliferation of malignant blood cells in the bone marrow. Tumor heterogeneity due to the acquisition of new somatic alterations leads to a high rate of resistance to current therapies or reduces the efficacy of hematopoietic...
The initial cause of periodontitis is thought to be dysbiosis, an imbalance in bacteria in the oral microbiota [18]. Bacterial biofilm accumulation causes an increase in the inflammatory infiltrates, which are primarily composed of neutrophils, within oral tissues. The neutrophils form a barrier in ...
At day 0, single-cell suspension of iPSC was seeded in the presence of ROCK inhibitor to produce aggregates called embryoid bodies (EB). After addition of Induction Medium for 2 days, the EB formed neural ectoderm and were then expanded in Matrigel droplets for a further 3 days to form ...
Ribothymidine, also known as 5-Methyluridine, is a pyrimidine nucleoside and methylated form of uridine. After entering the cell, ribothymidine is phosphorylated by kinases to mono- or triphosphates that inhibit viral replication. Ribothymidine is a key intermediate in the synthesis of anti-AIDS ...
More importantly, there are overlaps between those pathways and mechanisms and this is the reason why the exact pathogenesis of DN is still not fully understood. Pyroptosis, recently, has been identified as a novel form of programmed cell death accompanied by the release of numerous pro-...
The mechanical properties of single living cells have proven to be a powerful marker of the cell physiological state. The use of nanoindentation-based single cell force spectroscopy provided a wealth of information on the elasticity of cells, which is st
1) age range between 50 and 80 years; 2) diagnosis of less than 20 years; 3) patients exhibiting inadequate response to oral medication; 4) the patients themselves or their legal guardian must provide informed consent and sign the voluntary form in order to participate in this clinical trial...