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The internal heterogeneity of breast cancer, notably the tumor microenvironment (TME) consisting of malignant and non-malignant cells, has been extensively explored in recent years. The cells in this complex cellular ecosystem activate or suppress tumor
All patients and/or their family members were informed of the usage of the sample and signed the informed consent form. The human protocols were implemented strictly on the basis of the Ethical Guidelines of the Declaration of Helsinki. They were approved by the ethics committee of The Second ...
as well as transcriptional/epigenetic alterations, all leading to excessive proliferation of malignant blood cells in the bone marrow. Tumor heterogeneity due to the acquisition of new somatic alterations leads to a high rate of resistance to current therapies or reduces the efficacy of hematopoietic...
metabolites are found in pre-transplant samples, which seem to form more complex and robust networks, less dependent on specific interactions that support the topology of the network. For example, post-transplant non-GVHD samples are divided into two subnetworks that could fall apart by breaking ...
vicar created for platform either the designs are road signs logos in the form of printing projects unequal tailor made and many other characteristics which are unique. A huge library containing a lot of effects and different kind of designs that are dedicated to apply these changes to any pictu...
The mechanical properties of single living cells have proven to be a powerful marker of the cell physiological state. The use of nanoindentation-based single cell force spectroscopy provided a wealth of information on the elasticity of cells, which is st
Ribothymidine, also known as 5-Methyluridine, is a pyrimidine nucleoside and methylated form of uridine. After entering the cell, ribothymidine is phosphorylated by kinases to mono- or triphosphates that inhibit viral replication. Ribothymidine is a key intermediate in the synthesis of anti-AIDS ...
significantly increases the mRNA and protein expression levels of G protein-coupled receptor 55 (GPR55) via miR-7116-5p. In addition, GPR55 was found to inhibit the proliferation of Th1 cells via the extracellular regulatory protein kinase (ERK) signaling pathway, exacerbating MPE production [11]...
Two days after wounding, keratinocytes of the wound edge migrate into the wound bed and start to form a neo-epidermis. Basal keratinocytes of the neo-epidermis are strong producers of CCL27 throughout the re-epithelialization period. Next to CCL27, basal keratinocytes of the neo-epidermis also...