LEC progenitors produce Prox1, an important transcriptional factor for differentiation of LECs, in the cardinal vein of embryonic day (E) 10–11.5 mice. LEC progenitors accumulate to form pre-lymphatic clusters which sudsequently exit the cardinal vein wall to constitute superficial lymphatic vessels ...
Chemical structures of small molecule inhibitors of STAT3 (a-f). Full size image Lin and colleagues performed structure-based virtual screening of more than 425,000 compounds form four different chemical libraries to search a suitable STAT3 inhibitor. Out of top 200 compounds, they tested 100 chem...
Leung NHL, Chu DKW, Shiu EYC, Chan KH, McDevitt JJ, Hau BJP, et al. Respiratory virus shedding in exhaled breath and efficacy of face masks. Nat Med. 2020;26(5):676–80. Article CAS PubMed PubMed Central Google Scholar Chen P, Mao L, Nassis GP, Harmer P, Ainsworth BE, Li ...
The photoreceptors for red and far-red wavelengths are known as phytochromes and can have two different forms in the cell (Pr and Pfr) changing from one to other as a function of the red-light type. When plants are exposed to red light directly the Pr (inactive form) changes to Pfr (...
The current four interlocking rings logo came about in 1928. After four Audi competitors (Rasmussen's DKW, Wanderer and Horch) merged with Audi to form the Auto Union in 1932, the logo was changed to recognize the companies' equal and connected fates. ...
We read every piece of feedback, and take your input very seriously. Include my email address so I can be contacted Cancel Submit feedback Saved searches Use saved searches to filter your results more quickly Cancel Create saved search Sign in Sign up Reseting focus {...
To help the interpretation of these most descriptive pathways we calculated the fraction of genes carrying any form of somatic mutation, resulting into a mutational burden score. We then compared mutational burden across clusters via a Kruskal-Wallis test. P-values were corrected for multiple testing...
Mass spectrometric analysis demonstrated that flucloxacillin can covalently bind to proteins within immune cells and form flucloxacillin-modified peptides at the lysine residue (Waddington et al. Citation2020). In addition, the level of this binding correlated directly with the T-cell activation, ...
TAMs also promote the glycolysis and apoptotic resistance in cancer cells through sEVs transferring HISLA to block the degradation of HIF-1α. In contrast, glycolytic cancer cells release lactate to upregulate HISLA in TAMs to form a feed-forward loop [16]. Both these studies demonstrated that...
https://doi.org/10.1093/jac/dkw183. Article CAS PubMed Google Scholar van der Donk CF, Schols JM, Driessen CJ, Hagenouw RG, Meulendijks A, Stobberingh EE. Prevalence and spread of multidrug resistant Escherichia coli isolates among nursing home residents in the southern part of The ...