Apoptosis is a form of programmed cell death that plays a crucial role in maintaining the balance of cell numbers and the normal development and renewal of tissues under normal physiological conditions [59]. However, in kidney diseases, abnormal apoptosis may accelerate the progression of the diseas...
This study aimed to explore the clinical and pathological features of patients with diabetic kidney disease (DKD), with and without non-diabetic kidney disease (NDKD), through a retrospective analysis. The objective was to provide clinical insights for accurate identification. Methods A retrospective ...
is an iron-dependent form of cell death characterized by the accumulation of lipid reactive oxygen species (ROS) [15]. Unlike the formation of autophagosome in autophagy or nuclear fragmentation in apoptosis, ferroptosis is distinguished by diminished mitochondrial size, increased mitochondrial...
Due to the high prevalence of DKD, which increases disease-related morbidity and mortality, present approaches focus on prevention and early treatment [10]. Prior research highlights the importance of inflammation and oxidative stress to the onset of CKD [11]. Inflammatory processes are capable of ...
In recent years, it has been found that the renal damage caused by diabetes is not only limited to the glomerulu, but also the renal tubule play a key role in the early and progressive stages of DKD, and are an important “driver” for the development of DKD [1]. In other words, ...
Moreover, metabolites such as the oxidized form of nicotinamide adenine dinucleotide (NAD+) can orchestrate transcription and differentiation [56]. Studies have found that glycolysis mainly provides most of the energy in the early stage of neuronal cell differentiation [54]. However, the levels of ...
Diabetic kidney disease (DKD) has been the leading cause of chronic kidney disease in developed countries. Evidence of the benefits of resveratrol (RES) for the treatment of DKD is accumulating. However, comprehensive therapeutic targets and underlying mechanisms through which RES exerts its effects ...
[96]. LRG1 plasma levels have been shown to correlate with the soluble form of the (pro)renin receptor, which is a well-known RAS initiator. It is still unclear, though, whether there is a direct interaction between RAS and LRG1 as the latter does not appear to promote the expression ...
Besides membranous vesicles, extracellular miRNAs can also form complex with either argonaute protein or high density lipoprotein (HDL). Vickers et al. found that HDL transported endogenous miRNAs and delivered them to cultured hepatocytes resulted in significant loss of conserved mRNA targets [21]. Ho...
Diabetic kidney disease (DKD) is a prevalent and severe complication of diabetes and plays a pivotal role in the pathogenesis and progression of DKD. However, the current clinical application of the treatment methods does not yield effective results. Tac