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Plants that contain brewing microorganisms are used in traditional fermentation starters, which are an essential part of local diet, nutrition, life, and health. Regionally, the plant species used and the microorganisms included in traditional fermentati
However, the anti-cancer efficacy of PF-543 has not yet been investigated in primary cancer models in vivo, thereby limiting its further translation. Methods Building upon the identification of the active form of SphK1 as a viable therapeutic target in human HCC specimens, we assessed the ...
exposures have gained more relevance in disease risk, onset, and prevention. Thus, the number of papers on paternal epigenetic inheritance of metabolic traits has also increased. This has created the need to systematize the current knowledge and identify trends and gaps in the published studies. Th...
The human KALRN gene, which encodes a complex, multifunctional Rho GDP/GTP exchange factor, has been linked to cardiovascular disease, psychiatric disorders and neurodegeneration. Examination of existing Kalrn knockout mouse models has focused only on ne
Dai C, Celestino JC, Okada Y, Luois DN, Fuller GN, Holland EC: PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes Dev. 2001, 15: 1913-1925. 10.1101/gad.903001 Article PubMed Cen...
The yeast Yarrowia lipolytica has the ability to accumulate a large fraction of its mass as neutral lipids, mainly in the form of triglycerides [1]. This, along with its genetic tractability, has made it an attractive model for the production of high value lipids and biofuel precursors [2, ...
reactivate the inactive form of a potent immunosuppressive agent mycophenolate mofetil and influence its pharmacokinetics [30,31]. Immunosuppressants also significantly altered the gut microbiome [9,32]. High doses of tacrolimus significantly altered the composition and structure of the gut microbiome [...
in less complex regions of the genome, such as introns, and is therefore difficult to map with short-read next-generation sequencing technology; and (4) since bisulfite works less well on double-stranded DNA than single-stranded DNA, less complex regions might form snap-back structures that ...