Expansion of (CTG)n•(CAG)n trinucleotide repeat (TNR) microsatellite sequences is the cause of more than a dozen human neurodegenerative diseases. (CTG)n and (CAG)n repeats form imperfectly base paired hairpins that tend to expand in vivo in a length-
13Department of Tumour Biology, INSERM U830, Paris, France; 14University of Grenoble Alpes, Grenoble Institut des Neurosciences, INSERM U1216, Grenoble, France; 15INSERM, U1216, Grenoble, France *Correspondence: Professor A Durr, Centre de Recherche de l'Institut du Cerveau et de la Moelle épi...
Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan Masayuki Nakamori, Hideki Hayakawa, Hana Tanaka, Masanori P. Takahashi & Hideki Mochizuki Program of Genetics & Genome Biology, The Hospital for Sick Children, The Peter Gilgan Centre for Research and Learning, Toront...
Department of Occupational Therapy, Washington University School of Medicine, St. Louis, MO, USA Joel Perlmutter Corresponding author Correspondence to Peg Nopoulos. Additional information Competing interests The authors declare that they have no competing interests. Authors' contributions PN secured funding...
1Institut du Cerveau et la Moelle épinière (ICM), Sorbonne Université, UPMC Univ Paris 06, Inserm U1127, CNRS UMR 7225, Hôpital Pitié-Salpêtrière, Paris, France 6Department of Neurology, AP-HP - Hopital Pitié-Salpêtrière, Reference center for rare or early dementias, Institute of ...
Download:Download full-size image Figure 2. SCA3 RAN polyQ proteins form aggregates. (a) Representative images of immunofluorescence staining for AUG-initiated and RAN polyQ proteins (green signal, anti-HA antibody) and RAN polyA proteins (red signal, anti-Myc antibody) in the HEK293T cells 48...
However, * Correspondence: Xueyi.Li@mgh.harvard.edu 1Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA Full list of author information is available at the end of the article the mechanism underlying reduced glucose usage is poorly ...
1Oxford Project to Investigate Memory and Ageing (OPTIMA), Radcliffe Infirmary, Oxford and University Department of Pharmacology, Mansfield Road, Oxford OX1 3QT, UK 2Genomics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford Correspondence to: D J Lehmann; ...
Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA, 22908, Box 801392, USA Shuqiu Zheng, Nima Ghitani, Jessica S Blackburn, Jeh-Ping Liu & Scott O Zeitlin Neuroscience Training Program, University of Wisconsin, Madison, WI, USA Nima Ghitani Molecular Pathol...
As a second messenger in a cell, inositol plays an important role in the form of inositol phosphates, which are important in signal transduction. In current study, the levels of these four metabolites were altered to normal by electro-acupuncture treatment while moxibustion treatment could regulate...